A dual-targeting peptide facilitates targeting anti-inflammation to attenuate atherosclerosis in ApoE-/- mice

被引：5

作者：

Wu, Bo ^{[1
,2
]}

Zhong, Yuanzhi ^{[1
,2
]}

Chen, Jinmin ^{[3
]}

Pan, Xianmei ^{[1
,2
]}

Fan, Xianglin ^{[1
,2
]}

Chen, Peier ^{[1
,2
]}

Fu, Chenxing ^{[1
,2
]}

Ou, Caiwen ^{[4
]}

Chen, Minsheng ^{[1
,2
]}

机构：

[1] Southern Med Univ, Dept Cardiol, Zhujiang Hosp, Guangzhou 510280, Peoples R China

[2] Guangdong Prov Ctr Biomed Engn Cardiovasc Dis, Guangzhou 510280, Peoples R China

[3] Guangzhou Med Univ, Cardiovasc Dept, Affiliated Hosp 1, Guangzhou 510120, Peoples R China

[4] Southern Med Univ, Affiliated Dongguan Hosp, Dongguan Peoples Hosp, Dongguan 523059, Peoples R China

来源：

CHEMICAL COMMUNICATIONS | 2022年 / 58卷 / 62期

基金：

中国国家自然科学基金;

关键词：

NF-KAPPA-B; ENDOTHELIAL DYSFUNCTION; SHEAR-STRESS; INHIBITION; ACTIVATION; EXPRESSION; CELLS;

D O I：

10.1039/d2cc01457b

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

We report a peptidic dual-targeting drug delivery platform (integrins targeting and self-assembly instructed by matrix metalloproteinases) towards inflamed endothelial cells, which improved the anti-inflammatory ability of the loaded drug (i.e., puerarin) in vitro and thus improved the antiatherogenic effect of the loaded drug (i.e., puerarin) in vivo.

引用

页码：8690 / 8693

页数：4

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