A dual-targeting peptide facilitates targeting anti-inflammation to attenuate atherosclerosis in ApoE-/- mice

被引：5
|
作者：
Wu, Bo [1 ,2 ]
Zhong, Yuanzhi [1 ,2 ]
Chen, Jinmin [3 ]
Pan, Xianmei [1 ,2 ]
Fan, Xianglin [1 ,2 ]
Chen, Peier [1 ,2 ]
Fu, Chenxing [1 ,2 ]
Ou, Caiwen [4 ]
Chen, Minsheng [1 ,2 ]
机构：
[1] Southern Med Univ, Dept Cardiol, Zhujiang Hosp, Guangzhou 510280, Peoples R China
[2] Guangdong Prov Ctr Biomed Engn Cardiovasc Dis, Guangzhou 510280, Peoples R China
[3] Guangzhou Med Univ, Cardiovasc Dept, Affiliated Hosp 1, Guangzhou 510120, Peoples R China
[4] Southern Med Univ, Affiliated Dongguan Hosp, Dongguan Peoples Hosp, Dongguan 523059, Peoples R China
来源：
CHEMICAL COMMUNICATIONS | 2022年 / 58卷 / 62期
基金：
中国国家自然科学基金;
关键词：
NF-KAPPA-B; ENDOTHELIAL DYSFUNCTION; SHEAR-STRESS; INHIBITION; ACTIVATION; EXPRESSION; CELLS;
D O I：
10.1039/d2cc01457b
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
We report a peptidic dual-targeting drug delivery platform (integrins targeting and self-assembly instructed by matrix metalloproteinases) towards inflamed endothelial cells, which improved the anti-inflammatory ability of the loaded drug (i.e., puerarin) in vitro and thus improved the antiatherogenic effect of the loaded drug (i.e., puerarin) in vivo.
引用
收藏
页码：8690 / 8693
页数：4
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