A comparative study of anti-aging properties and mechanism: resveratrol and caloric restriction

被引：84

作者：

Li, Juan ^{[1
]}

Zhang, Chun-Xia ^{[1
]}

Liu, Yi-Mei ^{[1
]}

Chen, Ke-Li ^{[1
]}

Chen, Gang ^{[1
,2
]}

机构：

[1] Hubei Univ Chinese Med, Minist Educ Tradit Chinese Med Resource & Compoun, Key Lab, Wuhan 430065, Hubei, Peoples R China

[2] Hubei Coll Chinese Med, Jingzhou 434020, Hubei, Peoples R China

来源：

ONCOTARGET | 2017年 / 8卷 / 39期

基金：

中国博士后科学基金;

关键词：

resveratrol; caloric restriction; SIRT1; aging; OXIDATIVE DAMAGE; SIRT1; SURVIVAL; SUPPLEMENTATION; METABOLISM; ACTIVATORS; MELATONIN; STRESS; HEALTH; MICE;

D O I：

10.18632/oncotarget.20084

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Resveratrol and caloric restriction (CR) are the powerful therapeutic options for anti-aging. Here, their comparative effect on longevity-associated gene silencing information regulator (SIRT1) were evaluated in vitro and in vivo. IMR-90 cells treated with 2,2'-azobis (2-amidinopropane) dihydrochloride (AAPH) were applied to establish a cellular senescence model, and rats treated with D-galactose (D-gal) were used as an aging animal model. Resveratrol and CR exhibited similar anti-aging activities, evidenced by inhibiting senescence and apoptosis, and restoring cognitive impairment and oxidative damage. Moreover, they could up-regulate telomerase (TE) activity, increase expressions of SIRT1, forkhead box 3a (Foxo3a), active regulator of SIRT1 (AROS) and Hu antigen R (HuR), but decrease p53 and deleted in breast cancer 1 (DBC1) levels. However, 10 mu M resveratrol in vitro and the high dose group in vivo showed relatively stronger activities of anti-aging and stimulating SIRT1 level than CR. In conclusion, resveratrol and CR showed similar anti-aging activities on SIRT1 signaling, implicating the potential of resveratrol as a CR mimetic.

引用

页码：65717 / 65729

页数：13

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