A new mass screening test for color-vision deficiencies in children

被引:0
作者
Neitz, M
Neitz, J
机构
[1] Med Coll Wisconsin, Dept Ophthalmol, Milwaukee, WI 53226 USA
[2] Med Coll Wisconsin, Dept Cellular Biol, Milwaukee, WI 53226 USA
关键词
color vision; color vision deficiency; genetics; genetic test; deuteranopia; protanopia;
D O I
10.1002/1520-6378(2001)26:1+<::AID-COL51>3.3.CO;2-C
中图分类号
O69 [应用化学];
学科分类号
081704 ;
摘要
Five thousand one hundred and twenty-nine Wisconsin children, ages 4-12 years, were tested for color-vision deficiencies using a newly devised, precisely calibrated paper-and-pencil test. The disposable I-page test consisted of 2 demonstration and 8 test panels. Thousands of copies of the test were produced, and they were distributed and administered in classrooms by teachers. Children wrote directly on the test and were allowed to trace over the symbols,vith a pencil or crayon, if they had difficulty. Performance on the paper-and-pencil color vision test was compared with that on conventional tests of color vision including Ishihara's tests, the American Optical-Hardy Rand and Rittler (AO-HRR) plate test, and the APT-5 Color Vision Tester. Older children were also tested on the Nagel Anomaloscope. All the children who were classified as having a color vision deficiency by the paper-and-pencil test also failed one or more of the conventional tests. Likewise, among children who passed the paper-and-pencil test, none were classified as having a color-vision defect from the results on the conventional tests. In the sample of all males, 7.5% were classified as having a color-vision deficiency, which is consistent with what has been observed previously in large population studies. Children who were classified as having color vision deficiencies were examined further using a new minimalist generic test that was shown to be accurate and reliable. Genetic material derived from buccal swabs was used to determine the type of deficiency, protan vs. deutan, and to provide added information about severity. Among the subjects for whom type could be determined, 27% were protans, consistent with large population studies in which apyroximately 25% of red-green deficiencies have been found to be of the protan type. Classification of the severity of the deficiencies determined from the paper-and pencil test plus minimal genetics were in good agreement with classification based on a battery of conventional tests. In conclusion, we found the methods used here to be rapid efficient, and reliable for testing color vision in children. (C) 2000 John Wiley & Sons, Inc.
引用
收藏
页码:S239 / S249
页数:11
相关论文
共 30 条
[1]   MOLECULAR DETERMINANTS OF HUMAN RED/GREEN COLOR DISCRIMINATION [J].
ASENJO, AB ;
RIM, J ;
OPRIAN, DD .
NEURON, 1994, 12 (05) :1131-1138
[2]  
Bollinger K, 2001, COLOR RES APPL, V26, pS100, DOI 10.1002/1520-6378(2001)26:1+<::AID-COL23>3.0.CO
[3]  
2-I
[4]   Severity of color vision defects: electroretinographic (ERG), molecular and behavioral studies [J].
Crognale, MA ;
Teller, DY ;
Motulsky, AG ;
Deeb, SS .
VISION RESEARCH, 1998, 38 (21) :3377-3385
[5]  
DEEB SS, 1992, AM J HUM GENET, V51, P687
[6]   Variations in cone populations for red-green color vision examined by analysis of mRNA [J].
Hagstrom, SA ;
Neitz, J ;
Neitz, M .
NEUROREPORT, 1998, 9 (09) :1963-1967
[7]   Position of a 'green-red' hybrid gene in the visual pigment array determines colour-vision phenotype [J].
Hayashi, T ;
Motulsky, AG ;
Deeb, SS .
NATURE GENETICS, 1999, 22 (01) :90-93
[8]  
JACOBS GH, 1993, COLOR VISION DEFICIE, V11
[9]   ABSORPTION-SPECTRA OF THE HYBRID PIGMENTS RESPONSIBLE FOR ANOMALOUS COLOR-VISION [J].
MERBS, SL ;
NATHANS, J .
SCIENCE, 1992, 258 (5081) :464-466
[10]   ROLE OF HYDROXYL-BEARING AMINO-ACIDS IN DIFFERENTIALLY TUNING THE ABSORPTION-SPECTRA OF THE HUMAN RED AND GREEN CONE PIGMENTS [J].
MERBS, SL ;
NATHANS, J .
PHOTOCHEMISTRY AND PHOTOBIOLOGY, 1993, 58 (05) :706-710