Control of DNA replication: A new facet of Hox proteins?

被引：14
作者：
Miotto, Benoit [1 ]
Graba, Yacine [2 ]
机构：
[1] Univ Paris 07, CNRS, Epigenet & Destin Cellulaire UMR7216, F-75251 Paris, France
[2] Univ Mediterranee, CNRS, IBDML, Inst Biol Dev Marseille Luminy, Marseille, France
来源：
BIOESSAYS | 2010年 / 32卷 / 09期
关键词：
DNA replication; Geminin; homeodomain; Hox; transcription; ORIGIN RECOGNITION COMPLEX; CELL-CYCLE; ANTENNAPEDIA HOMEOBOX; SEGMENTATION CLOCK; POU HOMEODOMAIN; GENE-REGULATION; MESSENGER-RNA; RETINAL AXONS; IN-VIVO; GEMININ;
D O I：
10.1002/bies.201000048
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Hox proteins are well-known as developmental transcription factors controlling cell and tissue identity, but recent findings suggest that they are also part of the cell replication machinery. Hox-mediated control of transcription and replication may ensure coordinated control of cell growth and differentiation, two processes that need to be tightly and precisely coordinated to allow proper organ formation and patterning. In this review we summarize the available data linking Hox proteins to the replication machinery and discuss the developmental and pathological implications of this new facet of Hox protein function.
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收藏
页码：800 / 807
页数：8
相关论文
共 84 条
  • [71] The Hox genes and their roles in oncogenesis
    Shah, Nilay
    Sukumar, Saraswati
    [J]. NATURE REVIEWS CANCER, 2010, 10 (05) : 361 - 371
  • [72] PROGRESSION OF THE CELL-CYCLE THROUGH MITOSIS LEADS TO ABORTION OF NASCENT TRANSCRIPTS
    SHERMOEN, AW
    OFARRELL, PH
    [J]. CELL, 1991, 67 (02) : 303 - 310
  • [73] Experience-dependent transfer of Otx2 homeoprotein into the visual cortex activates postnatal plasticity
    Sugiyama, Sayaka
    Di Nardo, Ariel A.
    Aizawa, Shinichi
    Matsuo, Isao
    Volovitch, Michel
    Prochiantz, Alain
    Hensch, Takao K.
    [J]. CELL, 2008, 134 (03) : 508 - 520
  • [74] Repression of origin assembly in metaphase depends on inhibition of RLF-B/Cdt1 by geminin
    Tada, S
    Li, A
    Maiorano, D
    Méchali, M
    Blow, JJ
    [J]. NATURE CELL BIOLOGY, 2001, 3 (02) : 107 - 113
  • [75] Eukaryotic DNA replication: from pre-replication complex to initiation complex
    Takisawa, H
    Mimura, S
    Kubota, Y
    [J]. CURRENT OPINION IN CELL BIOLOGY, 2000, 12 (06) : 690 - 696
  • [76] Role of interactions between the origin recognition complex and SIR1 in transcriptional silencing
    Triolo, T
    Sternglanz, R
    [J]. NATURE, 1996, 381 (6579) : 251 - 253
  • [77] Sequence-independent DNA binding and replication initiation by the human origin recognition complex
    Vashee, S
    Cvetic, C
    Lu, WY
    Simancek, P
    Kelly, TJ
    Walter, JC
    [J]. GENES & DEVELOPMENT, 2003, 17 (15) : 1894 - 1908
  • [78] HOX GENES AND VERTEBRATE AXIAL PATTERN
    Wellik, Deneen M.
    [J]. HOX GENES, 2009, 88 : 257 - +
  • [79] Extracellular Engrailed Participates in the Topographic Guidance of Retinal Axons In Vivo
    Wizenmann, Andrea
    Brunet, Isabelle
    Lam, Joyce S. Y.
    Sonnier, Laure
    Beurdeley, Marine
    Zarbalis, Konstantinos
    Weisenhorn-Vogt, Daniela
    Weinl, Christine
    Dwivedy, Asha
    Joliot, Alain
    Wurst, Wolfgang
    Holt, Christine
    Prochiantz, Alain
    [J]. NEURON, 2009, 64 (03) : 355 - 366
  • [80] Inhibition of eukaryotic DNA replication by geminin binding to Cdt1
    Wohlschlegel, JA
    Dwyer, BT
    Dhar, SK
    Cvetic, C
    Walter, JC
    Dutta, A
    [J]. SCIENCE, 2000, 290 (5500) : 2309 - +
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