Control of DNA replication: A new facet of Hox proteins?

被引：14
作者：
Miotto, Benoit [1 ]
Graba, Yacine [2 ]
机构：
[1] Univ Paris 07, CNRS, Epigenet & Destin Cellulaire UMR7216, F-75251 Paris, France
[2] Univ Mediterranee, CNRS, IBDML, Inst Biol Dev Marseille Luminy, Marseille, France
来源：
BIOESSAYS | 2010年 / 32卷 / 09期
关键词：
DNA replication; Geminin; homeodomain; Hox; transcription; ORIGIN RECOGNITION COMPLEX; CELL-CYCLE; ANTENNAPEDIA HOMEOBOX; SEGMENTATION CLOCK; POU HOMEODOMAIN; GENE-REGULATION; MESSENGER-RNA; RETINAL AXONS; IN-VIVO; GEMININ;
D O I：
10.1002/bies.201000048
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Hox proteins are well-known as developmental transcription factors controlling cell and tissue identity, but recent findings suggest that they are also part of the cell replication machinery. Hox-mediated control of transcription and replication may ensure coordinated control of cell growth and differentiation, two processes that need to be tightly and precisely coordinated to allow proper organ formation and patterning. In this review we summarize the available data linking Hox proteins to the replication machinery and discuss the developmental and pathological implications of this new facet of Hox protein function.
引用
收藏
页码：800 / 807
页数：8
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