Puupehenol, a Potent Antioxidant Antimicrobial Meroterpenoid from a Hawaiian Deep-Water Dactylospongia sp Sponge

被引：35

作者：

Hagiwara, Kehau ^{[1
]}

Hernandez, Jaaziel E. Garcia ^{[1
]}

Harper, Mary Kay ^{[2
]}

Carroll, Anthony ^{[3
]}

Motti, Cherie A. ^{[4
]}

Awaya, Jonathan ^{[5
]}

Hoang-Yen Nguyen ^{[5
]}

Wright, Anthony D. ^{[1
]}

机构：

[1] Univ Hawaii, DKI Coll Pharm, Hilo, HI 96720 USA

[2] Univ Utah, Dept Med Chem, Salt Lake City, UT 84112 USA

[3] Griffith Univ, Sch Environm, Brisbane, Qld 4222, Australia

[4] Australian Inst Marine Sci, Townsville, Qld 4810, Australia

[5] Univ Hawaii, Dept Biol, Hilo, HI 96720 USA

来源：

JOURNAL OF NATURAL PRODUCTS | 2015年 / 78卷 / 02期

关键词：

SESQUITERPENOID QUINONE; ABSOLUTE-CONFIGURATIONS; MARINE; STEREOCHEMISTRY; METABOLITES; POWER; ACID;

D O I：

10.1021/np500793g

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

From the organic extract of a deep-water Hawaiian sponge Dactylospongia sp., a new potent antioxidant and antimicrobial meroterpenoid, puupehenol (1), was isolated. The structure of 1 was determined using spectroscopic techniques (H-1 and C-13 NMR, MS, IR, UV, [alpha](D)). The known compound puupehenone (2) was also isolated and suggested as a probable artifact of the isolation procedures. Complete unambiguous H-1 and C-13 NMR data are provided for compounds 1 and 2. Bioassays performed with 1 and 2 showed them both to be very effective antioxidants and to have antimicrobial properties.

引用

页码：325 / 329

页数：5

共 24 条

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