Label-Free Analysis of DNA Methylation using Optofluidic Ring Resonators

被引：1

作者：

Suter, Jonathan D. ^{[1
]}

Howard, Daniel J. ^{[1
]}

Shi, Huidong ^{[2
]}

Caldwell, Charles W. ^{[3
]}

Fan, Xudong ^{[1
]}

机构：

[1] Univ Missouri, Dept Biol Engn, Columbia, MO 65211 USA

[2] Med Coll Georgia Canc Ctr, Augusta, GA 30912 USA

[3] Univ Missouri, Dept Pathol & Anatom Sci, Columbia, MO 65211 USA

来源：

2009 ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY, VOLS 1-20 | 2009年

关键词：

BIOMOLECULE DETECTION; SENSORS;

D O I：

10.1109/IEMBS.2009.5333866

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

We demonstrate the utility of the opto-fluidic ring resonator (OFRR) sensor for analyzing methylated oligonucleotides. Cytosine methylation, a regular epigenetic function in cellular growth and metabolism, may have ties to abnormal suppression of key genes involved with cellular proliferation. Such behavior is suspected to be strongly related to the occurrence of several types of cancers. The OFRR is demonstrated as a tool both for detecting DNA hybridization and methylated cytosines residues.

引用

页码：2760 / 2762

页数：3

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