Differential Expression of Cyclic Nucleotide Phosphodiesterases 4 in Developing Rat Lung
被引:5
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作者:
Lopez, Emmanuel
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h-index: 0
机构:
Univ Paris 05, Fac Med, Paris, France
PremUP, Paris, France
Grp Hosp Cochin St Vincent de Paul, AP HP, Serv Med Neonatale Port Royal, Paris, FranceHop St Vincent de Paul, Inserm Paris Descartes, UMR 767, F-75014 Paris, France
Lopez, Emmanuel
[2
,3
,4
]
Jarreau, Pierre-Henri
论文数: 0引用数: 0
h-index: 0
机构:
Univ Paris 05, Fac Med, Paris, France
PremUP, Paris, France
Grp Hosp Cochin St Vincent de Paul, AP HP, Serv Med Neonatale Port Royal, Paris, FranceHop St Vincent de Paul, Inserm Paris Descartes, UMR 767, F-75014 Paris, France
Jarreau, Pierre-Henri
[2
,3
,4
]
Zana, Elodie
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h-index: 0
机构:
PremUP, Paris, FranceHop St Vincent de Paul, Inserm Paris Descartes, UMR 767, F-75014 Paris, France
Zana, Elodie
[3
]
Franco-Montoya, Marie-Laure
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h-index: 0
机构:
PremUP, Paris, France
Hop Henri Mondor, INSERM, U955, F-94010 Creteil, FranceHop St Vincent de Paul, Inserm Paris Descartes, UMR 767, F-75014 Paris, France
Franco-Montoya, Marie-Laure
[3
,5
]
Schmitz, Thomas
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机构:
Univ Paris 05, Fac Med, Paris, France
PremUP, Paris, France
Grp Hosp Cochin St Vincent de Paul, AP HP, Serv Obstet, Paris, FranceHop St Vincent de Paul, Inserm Paris Descartes, UMR 767, F-75014 Paris, France
Schmitz, Thomas
[2
,3
,6
]
Evain-Brion, Daniele
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h-index: 0
机构:
PremUP, Paris, FranceHop St Vincent de Paul, Inserm Paris Descartes, UMR 767, F-75014 Paris, France
Evain-Brion, Daniele
[3
]
Bourbon, Jacques
论文数: 0引用数: 0
h-index: 0
机构:
PremUP, Paris, France
Hop Henri Mondor, INSERM, U955, F-94010 Creteil, FranceHop St Vincent de Paul, Inserm Paris Descartes, UMR 767, F-75014 Paris, France
Bourbon, Jacques
[3
,5
]
Delacourt, Christophe
论文数: 0引用数: 0
h-index: 0
机构:
PremUP, Paris, France
Hop Henri Mondor, INSERM, U955, F-94010 Creteil, FranceHop St Vincent de Paul, Inserm Paris Descartes, UMR 767, F-75014 Paris, France
Delacourt, Christophe
[3
,5
]
Mehats, Celine
论文数: 0引用数: 0
h-index: 0
机构:
Hop St Vincent de Paul, Inserm Paris Descartes, UMR 767, F-75014 Paris, France
PremUP, Paris, FranceHop St Vincent de Paul, Inserm Paris Descartes, UMR 767, F-75014 Paris, France
Mehats, Celine
[1
,3
]
机构:
[1] Hop St Vincent de Paul, Inserm Paris Descartes, UMR 767, F-75014 Paris, France
[2] Univ Paris 05, Fac Med, Paris, France
[3] PremUP, Paris, France
[4] Grp Hosp Cochin St Vincent de Paul, AP HP, Serv Med Neonatale Port Royal, Paris, France
[5] Hop Henri Mondor, INSERM, U955, F-94010 Creteil, France
[6] Grp Hosp Cochin St Vincent de Paul, AP HP, Serv Obstet, Paris, France
During the perinatal period, lungs undergo changes to adapt to air breathing. The genes involved in these changes are developmentally regulated by various signaling pathways, including the cyclic nucleotide cAMP. As PDE4s are critical enzymes for regulation of cAMP levels, the objective of this study was to investigate PDE4's ontogeny in developing rat lung during the perinatal period. Pulmonary PDE4 activity, PDE4A-D, PDE4B, and PDE4D variant expression levels, PDE4B and PDE4D protein levels, and PDE4D localization in distal lung were determined. PDE4 activity increased towards term, dropped at birth, and increased thereafter to reach a plateau at the end of the second week of life. PDE4B2 and PDE4D long forms demonstrated a pattern of expression that increased markedly at birth. After birth, PDE4D was expressed in alveolar epithelial and mesenchymal cells. The study, therefore, evidenced striking variations in expression patterns among the PDE4 family that differed from changes in global PDE4 activity. Developmental Dynamics 239:2470-2478, 2010. (c) 2010 Wiley-Liss, Inc.