Sleep, Circadian Rhythms, and Epilepsy

被引：11
作者：
Daley, Joseph T. [1 ,2 ]
DeWolfe, Jennifer L. [1 ,2 ]
机构：
[1] Univ Alabama Birmingham, Dept Neurol, UAB Epilepsy Ctr, 1719 6th Ave South,312 CIRC, Birmingham, AL 35294 USA
[2] Birmingham VA Med Ctr, BVAMC Neurol Sleep Serv, 700 South 19th St, Birmingham, AL 35233 USA
来源：
CURRENT TREATMENT OPTIONS IN NEUROLOGY | 2018年 / 20卷 / 11期
关键词：
Circadian rhythms; Sleep disturbances in epilepsy; Sleep activated seizures; Epilepsy surgery; Neurostimulation; VAGUS NERVE-STIMULATION; TEMPORAL-LOBE EPILEPSY; EYE-MOVEMENT SLEEP; INTERICTAL EPILEPTIFORM DISCHARGES; DEEP BRAIN-STIMULATION; QUALITY-OF-LIFE; INTRACTABLE EPILEPSY; REM-SLEEP; REFRACTORY EPILEPSY; DAYTIME SLEEPINESS;
D O I：
10.1007/s11940-018-0534-1
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Purpose of reviewThere is a known interrelationship between sleep and epilepsy. This review highlights the recent findings regarding interactions between sleep and circadian rhythms and the manifestations of epilepsy and surgical treatments for refractory epilepsy.Recent findingsCLOCK gene expression may be reduced within the epileptogenic focus in patients with refractory epilepsy. Interictal epileptiform discharges during NREM and especially REM sleep may lateralize to the epileptogenic hemisphere. Intracranial video EEG monitoring and EEG from implanted responsive neurostimulator devices confirm scalp video EEG findings of a nocturnal peak for interictal epileptiform discharges. Successful epilepsy surgery may improve sleep macrostructure and quality.SummarySleep outcomes in people with epilepsy undergoing epilepsy surgery and neurostimulator implantation may provide innovative understandings into the associations between sleep and epilepsy. These associations may then provide novel therapeutic options targeting sleep and circadian pathways to improve seizure control and improve the quality of life for patients with this debilitating disorder.
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页数：10
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