Alteration of sensorimotor integration in musician's cramp:: impaired focusing of proprioception

被引:61
作者
Rosenkranz, K
Altenmüller, E
Siggelkow, S
Dengler, R [1 ]
机构
[1] Hannover Med Sch, Dept Neurol, D-30623 Hannover, Germany
[2] Acad Mus & Drama, Inst Mus Physiol & Performing Arts Med, Hannover, Germany
关键词
musician's cramp; muscle vibration; transcranial magnetic stimulation; motor-evoked potentials; sensorimotor integration;
D O I
10.1016/S1388-2457(00)00460-0
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Objective: The influence of muscle vibration (MV) as a strong proprioceptive input on motorcortical excitability was studied in 5 patients with musician's cramp, 5 musician controls and 5 non-musician controls Methods: The relaxed flexor carpi radialis (FCR), involved in the dystonic movement in all patients, was vibrated using low frequency (80 Hz) and low amplitude (0.5 mm). Transcranial magnetic stimulation (TMS; intensity, 120% of motor threshold) was applied without MV, 3 and 9 s after the onset of MV. Motor-evoked potentials (MEPs) in the FCR and in the antagonistic extensor carpi radialis (ECR) were recorded. Results: With MV, musician and non-musician controls showed a facilitation of MEPs in the FCR and a decrease of MEPs in the ECR. In musician's cramp, both phenomena were significantly less pronounced. Conclusions: The reduced facilitation of MEPs in musician's cramp indicates a reduced MV-induced activation of motorcortical areas representing the FCR. The less pronounced inhibition by MV reflects a reduced inhibitory control of the antagonistic ECR. As there were no differences between musician and non-musician controls, the observed changes in musician's cramp refer to this special form of focal dystonia. An impairment of focused motorcortical activation by proprioceptive input from a muscle involved in the dystonic movement is suggested. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.
引用
收藏
页码:2040 / 2045
页数:6
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