Emergence of diversity and stereochemical outcomes in the biosynthetic pathways of cyclobutane-centered marine alkaloid dimers

被引：80

作者：

Beniddir, Mehdi A. ^{[1
]}

Evanno, Laurent ^{[1
]}

Joseph, Delphine ^{[1
]}

Skiredj, Adam ^{[1
]}

Poupon, Erwan ^{[1
]}

机构：

[1] Univ Paris 11, Univ Paris Saclay, CNRS, BioCIS, F-92290 Chatenay Malabry, France

来源：

NATURAL PRODUCT REPORTS | 2016年 / 33卷 / 07期

关键词：

PYRROLE-IMIDAZOLE ALKALOIDS; VISIBLE-LIGHT PHOTOCATALYSIS; APLYSINOPSIN-TYPE ALKALOIDS; RAY CRYSTAL-STRUCTURE; BROMOPYRROLE ALKALOIDS; NATURAL-PRODUCTS; FAMILY DENDROPHYLLIIDAE; A-D; SECONDARY METABOLITES; ANTINEOPLASTIC AGENTS;

D O I：

10.1039/c5np00159e

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Dictazoles and sceptrins are singular metabolites of marine origin. The present dichotomic case study provides a comprehensive perspective on these cyclobutane-centered alkaloids and their respective families. Indeed, their upstream and downstream chemistry are both treated herein. Relevant isolation reports and bio-inspired total syntheses are used to decipher the currently admitted biosynthetic hypotheses as well as the emergence of diversity in the two series. This review proposes a transversal vision of the topic, where most aspects of natural product chemistry have a critical importance.

引用

页码：820 / 842

页数：23

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