[alpha]-Anellated carbazoles with antitumor activity: Synthesis and cytotoxicity

被引：13
|
作者：
Rogge, M [1 ]
Fischer, G [1 ]
Pindur, U [1 ]
Schollmeyer, D [1 ]
机构：
[1] UNIV MAINZ,INST ORGAN CHEM,D-55099 MAINZ,GERMANY
来源：
MONATSHEFTE FUR CHEMIE | 1996年 / 127卷 / 01期
关键词：
3-vinylindoles; carbazoles; Diels-Alder reactions; cytotoxicity;
D O I：
10.1007/BF00807414
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The cycloadducts 3, 5, and 7, readily available from methoxy-substituted 3-vinylindoles 1 and 2, were dehydrogenated with DDQ to the coplanar [a]-anellated carbazoles 4, 6, and 8. Compound 4a, also characterized by X-ray structural analysis, shows significant cytotoxicity against K562 und RXF393 human tumor cell lines.
引用
收藏
页码：97 / 102
页数：6
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