Selective ring N-protection of aminopyrazoles

被引：11

作者：

Seelen, W

Schäfer, M

Ernst, A

机构：

[1] Schering AG, Res Ctr Europe, Med Chem, D-13342 Berlin, Germany

[2] Schering AG, Res Ctr Europe, Struct Biol, D-13342 Berlin, Germany

来源：

TETRAHEDRON LETTERS | 2003年 / 44卷 / 24期

关键词：

D O I：

10.1016/S0040-4039(03)00988-2

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Two simple Procedures for the selective protection of the ring N of aminopyrazoles as tert-butoxycarbamate (Boc) in high yields are reported: several other protecting groups (Cbz, Bn. SEM) can be introduced using the one-pot procedure (method B). The N-Boc protected aminopyrazoles are acylated at the exocyclic NH2 group and subsequently deprotected to give the corresponding 3-acylaminopyrazoles in high yields. This procedure is applicable for the rapid parallel synthesis of 3-acylaminopyrazoles. (C) 2003, Elsevier Science Ltd. All rights reserved.

引用

页码：4491 / 4493

页数：3