Reducing Allostatic Load in Depression and Anxiety Disorders: Physical Activity and Yoga Practice as Add-On Therapies

被引：30

作者：

D'Alessio, Luciana ^{[1
,2
]}

Korman, Guido Pablo ^{[3
]}

Sarudiansky, Mercedes ^{[3
]}

Guelman, Laura Ruth ^{[4
]}

Scevola, Laura ^{[2
]}

Pastore, Alejandra ^{[5
]}

Obregon, Amilcar ^{[5
]}

Roldan, Emilio J. A. ^{[5
]}

机构：

[1] Univ Buenos Aires, Fac Med, IBCN, CONICET, Buenos Aires, DF, Argentina

[2] Univ Buenos Aires, Hosp Ramos Mejia, Buenos Aires, DF, Argentina

[3] Univ Buenos Aires, Fac Psicol, CAEA, CONICET, Buenos Aires, DF, Argentina

[4] Univ Buenos Aires, Fac Psicol, CEFYBO, CONICET, Buenos Aires, DF, Argentina

[5] Gador SA, Direccion Med & Cient, Buenos Aires, DF, Argentina

来源：

FRONTIERS IN PSYCHIATRY | 2020年 / 11卷

关键词：

chronic stress; neuroplasticity; neurogenesis; hippocampus; cortisol; noradrenaline; antidepressants; benzodiazepines; CORONARY-HEART-DISEASE; HIPPOCAMPAL NEUROGENESIS; METABOLIC SYNDROME; ANTIDEPRESSANT TREATMENT; STRESS REDUCTION; SEX-DIFFERENCES; MENTAL-HEALTH; ANIMAL-MODEL; EXERCISE; BRAIN;

D O I：

10.3389/fpsyt.2020.00501

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

The allostatic load (AL) index constitutes a useful tool to objectively assess the biological aspects of chronic stress in clinical practice. AL index has been positively correlated with cumulative chronic stress (physical and psychosocial stressors) and with a high risk to develop pathological conditions (e.g., metabolic syndrome, cardiovascular pathology, inflammatory disorders) and the so-called stress-related psychiatric disorders, including anxiety and depressive disorders. Chronic stress has negative effects on brain neuroplasticity, especially on hippocampal neurogenesis and these effects may be reversed by antidepressant treatments. Several evidences indicate that non-pharmacological interventions based on physical activity and yoga practice may add synergizing benefits to classical treatments (antidepressant and benzodiazepines) for depression and anxiety, reducing the negative effects of chronic stress. The aim of this review is to provide a general overview of current knowledge on AL and chronic stress in relation to depression and anxiety, physical activity and yoga practice.

引用

页数：10

共 127 条

[1] Gender Differences Relating to Metabolic Syndrome and Proinflammation in Finnish Subjects with Elevated Blood Pressure [J].