The Role of Inhibition of Apoptosis in Acute Leukemias and Myelodysplastic Syndrome

被引：33

作者：

McBride, Amanda ^{[1
]}

Houtmann, Sarah ^{[2
]}

Wilde, Lindsay ^{[1
]}

Vigil, Carlos ^{[3
]}

Eischen, Christine M. ^{[4
]}

Kasner, Margaret ^{[1
]}

Palmisiano, Neil ^{[1
]}

机构：

[1] Thomas Jefferson Univ, Dept Med Oncol, Sidney Kimmel Canc Ctr, Philadelphia, PA 19107 USA

[2] Thomas Jefferson Univ, Dept Med, Philadelphia, PA 19107 USA

[3] Univ Iowa, Dept Internal Med, Div Hematol Oncol & Blood & Marrow Transplantat, Iowa City, IA 52242 USA

[4] Thomas Jefferson Univ, Dept Canc Biol, Sidney Kimmel Canc Ctr, Philadelphia, PA 19107 USA

来源：

FRONTIERS IN ONCOLOGY | 2019年 / 9卷

关键词：

BCL-2; venetoclax; AML; ALL; MDS; intrinsic apoptosis; ACUTE MYELOID-LEUKEMIA; T-CELL DEVELOPMENT; ACUTE LYMPHOBLASTIC-LEUKEMIA; BCL-2 FAMILY PROTEINS; BH3 MIMETIC ABT-737; OBATOCLAX MESYLATE; OBLIMERSEN SODIUM; OLDER PATIENTS; OPEN-LABEL; PHASE-II;

D O I：

10.3389/fonc.2019.00192

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Avoidance of apoptosis is a key mechanism that malignancies, including acute leukemias and MDS, utilize in order to proliferate and resist chemotherapy. Recently, venetoclax, an inhibitor of the anti-apoptotic protein BCL-2, has been approved for the treatment of upfront AML in an unfit, elderly population. This paper reviews the pre-clinical and clinical data for apoptosis inhibitors currently in development for the treatment of AML, ALL, and MDS.

引用

页数：11

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