Ruthenium-Catalyzed Asymmetric Transfer Hydrogenation of Allylic Alcohols by an Enantioselective Isomerization/Transfer Hydrogenation Mechanism

被引：56
|
作者：
Wu, Ruoqiu [1 ]
Beauchamps, Marie G. [1 ]
Laquidara, Joseph M. [1 ]
Sowa, John R., Jr. [1 ]
机构：
[1] Seton Hall Univ, Dept Chem & Biochem, S Orange, NJ 07079 USA
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2012年 / 51卷 / 09期
关键词：
allylic alcohols; asymmetric catalysis; asymmetric transfer hydrogenation; isomerization; phosphine ligands; REDOX ISOMERIZATION; EFFICIENT; KETONES; REDUCTION; COMPLEXES; SCOPE; LIGANDS;
D O I：
10.1002/anie.201107910
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Reducing hazards: A asymmetric transfer hydrogen reaction was developed to reduce prochiral allylic alcohols in high yield and excellent enantioselectivity (see example). Mechanistic studies indicate a novel enantioselective isomerization/transfer hydrogenation mechanism. This new reaction is much safer than high-pressure hydrogenation using H 2 gas. Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
引用
收藏
页码：2106 / 2110
页数：5
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