Concise microwave-assisted synthesis of 2-aminoimidazole marine sponge alkaloids of the isonaamines series

被引：20

作者：

Ermolat'ev, D. S. ^{[1
]}

Alifanov, V. L. ^{[2
]}

Rybakov, V. B. ^{[2
]}

Babaev, E. V. ^{[2
]}

Van der Eycken, E. V. ^{[1
]}

机构：

[1] Univ Louvain, LOMAC, B-3001 Heverlee, Belgium

[2] Moscow MV Lomonosov State Univ, Dept Chem, Moscow 119991, Russia

来源：

SYNTHESIS-STUTTGART | 2008年 / 13卷 / 13期

关键词：

natural products; ring opening; cleavage; imidazo[1,2a]pyrimidin-1-ium salts; 2-aminoimidazoles;

D O I：

10.1055/s-2008-1078444

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A short and efficient route to 1,4-substituted 2-aminoimidazole alkaloids starting from the easily accessible 2-alkylaminopyrimidines and a.-bromo aldehydes is reported. The formation of the intermediate imidazo[1,2-a]pyrimidinium salts and subsequent cleavage were facilitated by microwave irradiation. Marine sponge alkaloids preclathridines A, C and isonaamines A, C, D were obtained in high yields using the optimized one-pot two-step procedure.

引用

页码：2083 / 2088

页数：6

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