Synthesis of derivatives of N-glycolylneuraminic acid ethylthioglycoside and their use as glycosyl donors

被引：0

作者：

Simeoni, LA ^{[1
]}

Bairamova, VE ^{[1
]}

Bovin, NV ^{[1
]}

机构：

[1] RUSSIAN ACAD SCI,SHEMYAKIN OVCHINNIKOV INST BIOORGAN CHEM,MOSCOW 117871,RUSSIA

来源：

BIOORGANICHESKAYA KHIMIYA | 1996年 / 22卷 / 08期

关键词：

N-acetylneuraminic acid; N-glycolylneuraminic acid; sialylation; sialosides; thioglycosides;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

The synthesis of a completely protected derivative of N-glycolylneuraminic acid thioglycoside from the corresponding derivative of N-acetylneuraminic acid via deprotection to the free thioglycoside followed by N-glycolylation, esterification, and acetylation was described. The reverse order of the stages of esterification and glycolylation resulted in the N-glycolylneuraminic acid derivative with two glycolylated hydroxyl groups. Both compounds obtained can be used as glycosyl, donors in the reactions of sialylation promoted with thiophilic agents.

引用

页码：599 / 605

页数：7

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