Synthesis of derivatives of N-glycolylneuraminic acid ethylthioglycoside and their use as glycosyl donors

被引：0
|
作者：
Simeoni, LA [1 ]
Bairamova, VE [1 ]
Bovin, NV [1 ]
机构：
[1] RUSSIAN ACAD SCI,SHEMYAKIN OVCHINNIKOV INST BIOORGAN CHEM,MOSCOW 117871,RUSSIA
来源：
BIOORGANICHESKAYA KHIMIYA | 1996年 / 22卷 / 08期
关键词：
N-acetylneuraminic acid; N-glycolylneuraminic acid; sialylation; sialosides; thioglycosides;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
The synthesis of a completely protected derivative of N-glycolylneuraminic acid thioglycoside from the corresponding derivative of N-acetylneuraminic acid via deprotection to the free thioglycoside followed by N-glycolylation, esterification, and acetylation was described. The reverse order of the stages of esterification and glycolylation resulted in the N-glycolylneuraminic acid derivative with two glycolylated hydroxyl groups. Both compounds obtained can be used as glycosyl, donors in the reactions of sialylation promoted with thiophilic agents.
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页码：599 / 605
页数：7
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