The pathogenesis of early retinal changes of diabetic retinopathy

被引：83

作者：

Arden, G. B. ^{[1
]}

Sivaprasad, S. ^{[2
]}

机构：

[1] City Univ London, London EC1V 0HB, England

[2] Kings Coll Hosp NHS Fdn Trust, London, England

来源：

DOCUMENTA OPHTHALMOLOGICA | 2012年 / 124卷 / 01期

关键词：

Diabetic retinopathy; Rods; Dark adaptation; VEGF; Oxidative stress hypoxia; ENDOTHELIAL GROWTH-FACTOR; IMPAIRED DARK-ADAPTATION; OXYGEN DISTRIBUTION; MACULAR EDEMA; ANTI-VEGF; VASCULAR-PERMEABILITY; CONTRAST SENSITIVITY; RETINITIS-PIGMENTOSA; GLIAL REACTIVITY; OXIDATIVE STRESS;

D O I：

10.1007/s10633-011-9305-y

中图分类号：

R77 [眼科学];

学科分类号：

100212 ;

摘要：

Recent successful trials of antibodies to vascular endothelial growth factor (VEGF) in diabetic retinopathy implicate this cytokine as a major cause of diabetic retinopathy (DR) and diabetic macular oedema (DME). The mechanisms which cause VEGF to be over-expressed to cause the vasculopathy are not entirely clear. This review explores the earliest changes to the retina in DR and the factors that predispose or prevent DR, including sleep apnoea, receptor degenerations laser treatment and VEGF polymorphism. The review also presents the evidence that retinal hypoxia, existing in the earliest stages, causes DR. This hypoxia is much increased by dark adaptation, indicating a new and possibly superior therapy.

引用

页码：15 / 26

页数：12

共 99 条

[1] Assessment of selected adhesion molecule and proinflammatory cytokine levels in the vitreous body of patients with type 2 diabetes - role of the inflammatory-immune process in the pathogenesis of proliferative diabetic retinopathy [J].