Penicillin and clindamycin differentially inhibit the production of pyrogenic exotoxins A and B by group A streptococci

被引：73

作者：

Mascini, EM

Jansze, M

Schouls, LM

Verhoef, J

Van Dijk, H

机构：

[1] Univ Utrecht, Med Ctr, Eijkman Winkler Inst Microbiol Infect Dis & Infla, NL-3508 GA Utrecht, Netherlands

[2] RIVM, Natl Inst Publ Hlth & Environm, Bilthoven, Netherlands

来源：

INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS | 2001年 / 18卷 / 04期

关键词：

group A streptococcal infection; exotoxin; penicillin; clindamycin;

D O I：

10.1016/S0924-8579(01)00413-7

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Streptococcal pyrogenic exotoxins A (SPE-A) and B (SPE-B) have been implicated in the pathogenesis of serious group A streptococcal infections including streptococcal toxic shock-syndrome. Current antibiotics used for the treatment of these infections are penicillin and clindamycin, The effects of sub- and suprainhibitory concentrations of penicillin and clindamycin were evaluated in 14 isolates of Streptococcus pyogenes that were fully susceptible to both antibiotics. Clindamycin was superior to penicillin in reducing the production of SPE-A and SPE-B by invasive and non-invasive Dutch group A streptococcal isolates in vitro. (C) 2001 Elsevier Science B.V. and International Society of Chemotherapy. All rights reserved.

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收藏

页码：395 / 398

页数：4

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