The Cyclin D1 G870A Polymorphism and Colorectal Cancer Susceptibility: A Meta-analysis of 20 Populations

被引:0
作者
Zhang, Lou Qian [2 ]
Huang, Xin-En [3 ]
Wang, Jun [4 ]
Shang, Jun Qing [1 ]
Bai, Jianling [5 ]
Liu, Fu Yin [4 ]
Guan, Xin [1 ]
Zhou, Jian Nong [1 ]
机构
[1] Nanjing Med Univ, Affiliated Canc Hosp, Dept Colorectal & Anal Surg, Nanjing, Peoples R China
[2] Nanjing Med Univ, Dept Med Oncol, Nanjing, Peoples R China
[3] Canc Hosp Jiangsu Prov, Dept Chemotherapy, Nanjing, Peoples R China
[4] Geriatr Inst Jiangsu Prov, Dept Chemotherapy, Nanjing, Peoples R China
[5] Nanjing Med Univ, Sch Publ Hlth, Dept Epidemiol & Biostat, Nanjing, Peoples R China
关键词
CyclinD1; polymorphism; colorectal cancer; meta-analysis; AGE-OF-ONSET; E-CADHERIN CDH1; A870G POLYMORPHISM; INCREASED RISK; ASSOCIATION; CCND1; EXPRESSION; VARIANTS; GENOTYPE; PROTEIN;
D O I
暂无
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Purpose: Studies of the association between the cyclin D1 (CCND1) G870A genetic polymorphism and risk of colorectal cancer (CRC) have generated conflicting results. In order to derive a more precise estimation, a meta-analysis was here performed. Materials and methods: An extensive search of relevant studies was carried out as a meta-analysis of twenty studies with 5,975 cases and 8,333 controls. Results: Overall, a significantly elevated colorectal cancer risk was associated with variant allele 870A when all studies were pooled (AA vs. GG: OR = 1.23, 95%CI = 1.04-1.44; GA vs. GG: OR = 1.13, 95%CI = 1.01-1.26; dominant model: OR = 1.16, 95%CI = 1.03-1.31). In the subgroup analysis by ethnicity, significantly increased risks were detected among Caucasians (AA vs. GG: OR = 1.27, 95%CI = 1.04-1.44; and dominant model: OR = 1.17, 95%CI = 1.02-1.34). With stratification into sporadic CRC and hereditary nonpolyposis colorectal cancer (HNPCC), the former demonstrated increased cancer susceptibility (AA vs. GG: OR = 1.24, 95%CI = 1.04-1.48; dominant model: OR = 1.17, 95%CI = 1.04-1.33). However, no significant associations were found in either Asians or HNPCC patients for any genetic model. Conclusion: The results suggest that the cyclin D1 870A allele is a low-penetrant risk factor for development of sporadic colorectal cancer, especially among Caucasians.
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页码:81 / 85
页数:5
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