Multiple functions of generic drugs: Future perspectives of Aureolic acid group of anti-cancer antibiotics and non-steroidal anti-inflammatory drugs

被引：19

作者：

Chakraborty, Hirak ^{[1
]}

Devi, Pukhrambam Grihanjali ^{[2
]}

Sarkar, Munna ^{[1
]}

Dasgupta, Dipak ^{[2
]}

机构：

[1] Saha Inst Nucl Phys, Div Chem Sci, Kolkata 700064, W Bengal, India

[2] Saha Inst Nucl Phys, Div Biophys, Kolkata 700064, W Bengal, India

来源：

MINI-REVIEWS IN MEDICINAL CHEMISTRY | 2008年 / 8卷 / 04期

关键词：

D O I：

10.2174/138955708783955944

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Non-steroidal anti-inflammatory drugs and aureolic acid group of anti-cancer drugs belong to the class of generic drugs. Research with some members of these two groups of drugs in different laboratories has unveiled functions other than those for which they were primarily developed as drugs. Here we have reviewed the molecular mechanism behind the multiple functions of these drugs that might lead to employ them for treatment of diseases in addition to those they are presently employed.

引用

页码：331 / 349

页数：19

共 174 条

[51]

Gambari R, 2000, J PHARMACOL EXP THER, V294, P370

[52] CHROMOMYCIN DIMER-DNA OLIGOMER COMPLEXES - SEQUENCE SELECTIVITY AND DIVALENT-CATION SPECIFICITY [J].

GAO, XL ;

PATEL, DJ .

BIOCHEMISTRY, 1990, 29 (49) :10940-10956

[53] Activity of flurbiprofen and chemically related anti-inflammatory drugs in models of Alzheimer's disease [J].

Gasparini, L ;

Ongini, E ;

Wilcock, D ;

Morgan, D .

BRAIN RESEARCH REVIEWS, 2005, 48 (02) :400-408

[54] Modulation of β-amyloid metabolism by non-steroidal anti-inflammatory drugs in neuronal cell cultures [J].

Gasparini, L ;

Rusconi, L ;

Xu, HX ;

del Soldato, P ;

Ongini, E .

JOURNAL OF NEUROCHEMISTRY, 2004, 88 (02) :337-348

[55]

Gebhardt M, 1995, Z RHEUMATOL, V54, P405

[56] A single amino acid difference between cyclooxygenase-1 (COX-1) and -2 (COX-2) reverses the selectivity of COX-2 specific inhibitors [J].

Gierse, JK ;

McDonald, JJ ;

Hauser, SD ;

Rangwala, SH ;

Koboldt, CM ;

Seibert, K .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1996, 271 (26) :15810-15814

[57] ANTIBIOTICS AND NUCLEIC ACIDS [J].

GOLDBERG, IH .

ANNUAL REVIEW OF BIOCHEMISTRY, 1971, 40 :775-+

[58] Meloxicam inhibits the growth of colorectal cancer cells [J].

Goldman, AP ;

Williams, CS ;

Sheng, HM ;

Lamps, LW ;

Williams, VP ;

Pairet, M ;

Morrow, JD ;

DuBois, RN .

CARCINOGENESIS, 1998, 19 (12) :2195-2199

[59] Induction of apoptosis by R-flurbiprofen in human colon carcinoma cells:: involvement of p53 [J].

Grösch, S ;

Schilling, K ;

Janssen, A ;

Maier, TJ ;

Niederberger, E ;

Geisslinger, G .

BIOCHEMICAL PHARMACOLOGY, 2005, 69 (05) :831-839

[60] The role of cyclooxygenase enzymes in the growth of human gall bladder cancer cells [J].

Grossman, EM ;

Longo, WE ;

Panesar, N ;

Mazuski, JE ;

Kaminski, DL .

CARCINOGENESIS, 2000, 21 (07) :1403-1409

← 1 2 3 4 5 6 7 8 9 10 →