Multiple functions of generic drugs: Future perspectives of Aureolic acid group of anti-cancer antibiotics and non-steroidal anti-inflammatory drugs

被引：19

作者：

Chakraborty, Hirak ^{[1
]}

Devi, Pukhrambam Grihanjali ^{[2
]}

Sarkar, Munna ^{[1
]}

Dasgupta, Dipak ^{[2
]}

机构：

[1] Saha Inst Nucl Phys, Div Chem Sci, Kolkata 700064, W Bengal, India

[2] Saha Inst Nucl Phys, Div Biophys, Kolkata 700064, W Bengal, India

来源：

MINI-REVIEWS IN MEDICINAL CHEMISTRY | 2008年 / 8卷 / 04期

关键词：

D O I：

10.2174/138955708783955944

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Non-steroidal anti-inflammatory drugs and aureolic acid group of anti-cancer drugs belong to the class of generic drugs. Research with some members of these two groups of drugs in different laboratories has unveiled functions other than those for which they were primarily developed as drugs. Here we have reviewed the molecular mechanism behind the multiple functions of these drugs that might lead to employ them for treatment of diseases in addition to those they are presently employed.

引用

页码：331 / 349

页数：19

共 174 条

[1] Indomethacin-induced apoptosis in esophageal adenocarcinoma cells involves upregulation of Bax and translocation of mitochondrial cytochrome c independent of COX-2 expression [J].

Aggarwal, S ;

Taneja, N ;

Lin, L ;

Orringer, MB ;

Rehemtulla, A ;

Beer, DG .

NEOPLASIA, 2000, 2 (04) :346-356

[2] ROLE OF MG++ IN THE MITHRAMYCIN-DNA INTERACTION - EVIDENCE FOR 2 TYPES OF MITHRAMYCIN-MG++ COMPLEX [J].

AICH, P ;

DASGUPTA, D .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1990, 173 (02) :689-696

[3] ROLE OF MAGNESIUM-ION IN THE INTERACTION BETWEEN CHROMOMYCIN-A3 AND DNA - BINDING OF CHROMOMYCIN-A3-MG2+ COMPLEXES WITH DNA [J].

AICH, P ;

SEN, R ;

DASGUPTA, D .

BIOCHEMISTRY, 1992, 31 (11) :2988-2997

[4] ROLE OF MAGNESIUM-ION IN MITHRAMYCIN DNA INTERACTION - BINDING OF MITHRAMYCIN MG2+ COMPLEXES WITH DNA [J].

AICH, P ;

DASGUPTA, D .

BIOCHEMISTRY, 1995, 34 (04) :1376-1385

[5] Inflammation and Alzheimer's disease [J].

Akiyama, H ;

Barger, S ;

Barnum, S ;

Bradt, B ;

Bauer, J ;

Cole, GM ;

Cooper, NR ;

Eikelenboom, P ;

Emmerling, M ;

Fiebich, BL ;

Finch, CE ;

Frautschy, S ;

Griffin, WST ;

Hampel, H ;

Hull, M ;

Landreth, G ;

Lue, LF ;

Mrak, R ;

Mackenzie, IR ;

McGeer, PL ;

O'Banion, MK ;

Pachter, J ;

Pasinetti, G ;

Plata-Salaman, C ;

Rogers, J ;

Rydel, R ;

Shen, Y ;

Streit, W ;

Strohmeyer, R ;

Tooyoma, I ;

Van Muiswinkel, FL ;

Veerhuis, R ;

Walker, D ;

Webster, S ;

Wegrzyniak, B ;

Wenk, G ;

Wyss-Coray, T .

NEUROBIOLOGY OF AGING, 2000, 21 (03) :383-421

[6] Novel GC-rich DNA-binding compound produced by a genetically engineered mutant of the mithramycin producer Streptomyces argillaceus exhibits improved transcriptional repressor activity:: implications for cancer therapy [J].

Albertini, V ;

Jain, A ;

Vignati, S ;

Napoli, S ;

Rinaldi, A ;

Kwee, I ;

Nur-e-Alam, M ;

Bergant, J ;

Bertoni, F ;

Carbone, GM ;

Rohr, J ;

Catapano, CV .

NUCLEIC ACIDS RESEARCH, 2006, 34 (06) :1721-1734

[7] AN INVIVO AND INVITRO INVESTIGATION OF THE PHOTOTOXIC POTENTIAL OF TENOXICAM, A NEW NONSTEROIDAL ANTIINFLAMMATORY AGENT [J].

ANDERSON, R ;

EFTYCHIS, HA ;

WEINER, A ;

FINDLAY, GH .

DERMATOLOGICA, 1987, 175 (05) :229-234

[8] Drug repositioning: Identifying and developing new uses for existing drugs [J].

Ashburn, TT ;

Thor, KB .

NATURE REVIEWS DRUG DISCOVERY, 2004, 3 (08) :673-683

[9] Spectroscopic studies of micro environment dictated structural forms of piroxicam and meloxicam [J].

Banerjee, R ;

Sarkar, M .

JOURNAL OF LUMINESCENCE, 2002, 99 (03) :255-263

[10] Meloxicam in acute UV dermatitis - a pilot study [J].

Bayerl, C ;

Pagung, R ;

Jung, EG .

PHOTODERMATOLOGY PHOTOIMMUNOLOGY & PHOTOMEDICINE, 1998, 14 (5-6) :167-169

← 1 2 3 4 5 6 7 8 9 10 →