Development of Global Consensus of Dengue Virus Envelope Glycoprotein for Epitopes Based Vaccine Design

被引：9

作者：

Hussain, Mazhar ^{[1
]}

Idrees, Muhammad ^{[1
]}

Afzal, Samia ^{[1
]}

机构：

[1] Natl Ctr Excellence Mol Biol, Lahore, Pakistan

来源：

CURRENT COMPUTER-AIDED DRUG DESIGN | 2015年 / 11卷 / 01期

关键词：

Dengue virus; consensus sequence; Envelope glycoprotein; phylogenetic analysis; in silico design; IMMUNE-RESPONSES; PREDICTION; SEQUENCE; BINDING; ALIGNMENT; PROTEIN; IDENTIFICATION; PHYLOGENY; PAKISTAN; SAMPLES;

D O I：

10.2174/1573409911666150529130134

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Dengue virus (DENV) is the member of Flaviviridae and causative agent of Dengue Haemorrhagic Fever and Dengue Shock Syndrome. Every year, around 70% of the world population is at risk, due to epidemic episodes orchestrated by one or more of its serotypes. So, a tetravalent DENV vaccine is needed which may induce the immune response against all four DENV serotypes. In this study, B-cell and T-cell epitopes have been predicted from the DENV envelope glycoprotein (E-g) using a consensus based approach in complement with the physico-chemical property (PCP) conservancy analysis. Through DENV-E-g analysis, a total of 7 PCP conserved, water soluble, in vitro and in vivo stable epitopes were predicted which may induce the B-cell and T-cell mediated anti-viral immune response.

引用

页码：84 / 97

页数：14

共 55 条

[1] De Novo modeling of Envelope 2 protein of HCV isolated from Pakistani patient and epitopes prediction for vaccine development [J].