New synthetic routes to the kainoids: a synthesis of kainic acid and its analogues

被引：11
|
作者：
Parsons, Philip J. [1 ]
Rushton, Stephen P. G. [1 ]
Panta, Raghava R. [1 ]
Murray, Adrian J. [1 ]
Coles, Martyn P. [1 ]
Lai, Jason [1 ]
机构：
[1] Univ Sussex, Sch Life Sci, Dept Chem, Brighton BN1 9QJ, E Sussex, England
来源：
TETRAHEDRON | 2011年 / 67卷 / 52期
关键词：
Excitatory amino acids; Nitrile oxide; Kainate; Ene-reaction; Isoxazolidinone; ENANTIOSELECTIVE TOTAL-SYNTHESIS; (-)-KAINIC ACID; (-)-ALPHA-KAINIC ACID; (+)-ALPHA-ALLOKAINIC ACID; CYCLIZATION; INSERTION;
D O I：
10.1016/j.tet.2011.10.030
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
New approaches to the synthesis of kainic acid and its analogues are presented. Two distinctly different approaches are described; the former utilised an intermolecular nitrile oxide addition to a homochiral substrate to furnish epikainate models and the second utilised amino acid chemistry to secure kainic acid. (C) 2011 Elsevier Ltd. All rights reserved.
引用
收藏
页码：10267 / 10273
页数：7
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