Influence of two barrier membranes on staged guided bone regeneration and osseointegration of titanium implants in dogs. Part 2: augmentation using bone graft substitutes

Objectives: To assess the influence of two barrier membranes and two bone graft substitutes on staged guided bone regeneration and osseointegration of titanium implants in dogs. Materials and methods: Saddle-type defects were prepared in the lower jaws of 6 fox hounds and randomly filled with a natural bone mineral (NBM) and a biphasic calcium phosphate (SBC) and allocated to either an in situ gelling polyethylene glycol (PEG) or a collagen membrane (CM). At 8 weeks, modSLA titanium implants were inserted and left to heal in a submerged position. At 8 + 2 weeks, respectively, dissected blocks were processed for histomorphometrical analysis (e. g., mineralized tissue [MT], bone-to-implant contact [BIC]). Results: The mean MT values (mm 2) and BIC values (%) tended to be higher in the PEG groups (MT: NBM [3.4 +/- 1.7]; SBC [4.2 +/- 2]/BIC: NBM [67.7 +/- 16.9]; SBC [66.9 +/- 17.8]) when compared with the corresponding CM groups (MT: NBM [2.5 +/- 0.8]; SBC [2.3 +/- 1.6]/BIC: NBM [54.1 +/- 22.6]; SBC [61 +/- 8.7]). These differences, however, did not reach statistical significance. Conclusion: It was concluded that all augmentation procedures investigated supported bone regeneration and staged osseointegration of modSLA titanium implants.