A flavonoid from medicinal plants blocks hepatitis B virus-e antigen secretion in HBV-infected hepatocytes

被引：103
作者：
Shin, MS [1 ]
Kang, EH [1 ]
Lee, YI [1 ]
机构：
[1] Korea Res Inst Biosci & Biotechnol, Biosci Res Div, Liver Cell Signal Transduct Lab, Taejon 305606, South Korea
来源：
ANTIVIRAL RESEARCH | 2005年 / 67卷 / 03期
关键词：
hepatitis B virus-e antigen; Phyllanthus urinaria; NMR spectrometer; HBeAg secretion;
D O I：
10.1016/j.antiviral.2005.06.005
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
A flavonoid molecule that showed a unique anti-HBV function was isolated from Phyllanthus urinaria. The molecular formula was determined as C14H6O8 based on FAM-MS analysis and the structure was determined by NMR. The identified flavonoid molecule, ellagic acid, showed unique anti-HBV functions. Ellagic acid did not inhibit either HBV polymerase activity, HBV replication or block HBsAg secretion. Rather, ellagic acid blocks effectively HBeAg secretion in HepG2 2.2.15 cells (IC50 = 0.07 mu g/ml). Since HBeAg is involved in immune tolerance during HBV infection, ellagic acid, a newly identified functional anti-HBV compound, may be a new candidate therapeutic against immune tolerance in HBV-infected individuals. (C) 2005 Published by Elsevier B.V.
引用
收藏
页码：163 / 168
页数：6
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