Soft Particles of Gemini Surfactant/Conjugated Polymer for Enhanced Anticancer Activity of Chemotherapeutics

被引：26
|
作者：
Wang, Hua [1 ,3 ]
Zhao, Weiwei [1 ,3 ]
Zhou, Lingyun [2 ,3 ]
Wang, Jianwu [2 ,3 ]
Liu, Libing [2 ]
Wang, Shu [2 ,3 ]
Wang, Yilin [1 ,3 ]
机构：
[1] Chinese Acad Sci, Inst Chem, CAS Res Educ Ctr Excellence Mol Sci, Key Lab Colloid Interface & Chem Thermodynam, Beijing 100190, Peoples R China
[2] Chinese Acad Sci, Inst Chem, CAS Res Educ Ctr Excellence Mol Sci, Key Lab Organ Solids,BNLMS, Beijing 100190, Peoples R China
[3] Univ Chinese Acad Sci, Beijing 100049, Peoples R China
来源：
ACS APPLIED MATERIALS & INTERFACES | 2018年 / 10卷 / 01期
基金：
中国国家自然科学基金;
关键词：
gemini surfactant; conjugated polymer; light irradiation; cell membrane permeability; anticancer activity; CANCER-THERAPY; DRUG-DELIVERY; NANOPARTICLES; RELEASE; NANOMEDICINE; SURFACTANTS; PACLITAXEL; SYSTEMS; AGENTS; CELLS;
D O I：
10.1021/acsami.7b16396
中图分类号：
TB3 [工程材料学];
学科分类号：
0805 ; 080502 ;
摘要：
In this work, we developed a kind of novel nontoxic soft particle self-assembled by gemini surfactant (SDHC) and conjugated polymer (PMNT). The soft particle shows strong ability in incorporating into cell membrane, and alters the membrane permeability, especially under light irradiation. The anticancer activities of doxorubicin (DOX) were enhanced 6-9 times after cancer cells were treated with the soft particles under light irradiation. The cell viabilities of three kinds of cancer cells testify that this effect of the soft particles on chemotherapy is universal. This work provides a new strategy to enhance the anticancer activities of drugs.
引用
收藏
页码：37 / 41
页数：5
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