Inefficacy of high-dose transdermal fentanyl in a patient with neuropathic pain, a case report

被引：26
|
作者：
Bleeker, CP [1 ]
Bremer, RC [1 ]
Dongelmans, DA [1 ]
van Dongen, RTM [1 ]
Crul, BJP [1 ]
机构：
[1] Univ Nijmegen Hosp, Dept Anaesthesiol, Pain Ctr, Pain Clin, NL-6500 HB Nijmegen, Netherlands
来源：
EUROPEAN JOURNAL OF PAIN-LONDON | 2001年 / 5卷 / 03期
关键词：
fentanyl; transdermal; opioid tolerance; neuropathic pain; side effects;
D O I：
10.1053/eujp.2000.0220
中图分类号：
R614 [麻醉学];
学科分类号：
100217 ;
摘要：
Pain partially responsive to opioids can lead to rapid escalating dosages due to tolerance development. In this report the case of a 58-year-old female with neuropathic pain using increasing transdermal (TTS) fentanyl dosages to a maximum dose of 3400 mug/h resulting in fentanyl plasma levels of 173 ng/ml is described. For pain relief an epidural infusion at the level T1-2 with bupivacaine was started. Immediate pain relief was accompanied by short lasting respiratory depression and drowsiness. (C) 2001 European Federation of Chapters of the International Association for the study of Pain.
引用
收藏
页码：325 / 329
页数：5
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