Daytime napping and diabetes-associated kidney disease

被引：13

作者：

Franke, Franziska J. ^{[1
]}

Arzt, Michael ^{[1
]}

Kroner, Tanja ^{[1
]}

Gorski, Mathias ^{[3
]}

Heid, Iris M. ^{[3
]}

Boeger, Carsten A. ^{[2
]}

Jung, Bettina ^{[2
]}

Zeman, Florian ^{[4
]}

Stadler, Stefan ^{[1
]}

Andreae, Axel ^{[5
]}

Haas, Gerhard ^{[5
]}

Haas, Sabine ^{[5
]}

Manz, Jochen ^{[5
]}

Nusser, Johann ^{[5
]}

Kreisel, Guenther ^{[5
]}

Bawidamann, Gerhard ^{[5
]}

Mader, Frederik ^{[5
]}

Kisskalt, Susanne ^{[5
]}

Hartl, Johann ^{[5
]}

Segiet, Thomas ^{[5
]}

Gleixner, Christiane ^{[5
]}

Scholz, Christian ^{[5
]}

Schober, Monika ^{[5
]}

Heinrich, Cornelia ^{[6
]}

Bohnhoff, Thomas ^{[7
]}

Heilmann, Thomas ^{[8
]}

Stern, Stefan ^{[6
]}

Utz, Andreas ^{[6
]}

Zellner, Georg ^{[9
]}

Ettl, Werner ^{[10
]}

Buck, Thomas ^{[10
]}

Bleek, Rainer ^{[11
]}

Blaudzun, Ulrich ^{[11
]}

Neumeier, Simone

Hufnagel, Sarah

Haller, Isabel

Jackermeier, Petra

Obermuller, Sabrina

Ried, Christiane

Hanauer, Ulrike

Sendtner, Barbel

Riewe-Kerow, Natalia

Dumann, Konstantin

Hormann, Britta

机构：

[1] Univ Hosp Regensburg, Dept Internal Med 2, Franz Josef Strauss Allee 11, D-93055 Regensburg, Germany

[2] Univ Hosp Regensburg, Dept Nephrol, Regensburg, Germany

[3] Univ Regensburg, Dept Genet Epidemiol, Regensburg, Germany

[4] Univ Hosp Regensburg, Dept Biometry, Ctr Clin Studies, Regensburg, Germany

[5] Allgemeine Ortskrankenkasse Bayern, Supply Management, Munich, Germany

[6] Allgemeine Ortskrankenkasse Bayern, Munich, Germany

[7] Techniker Krankenkasse, Dis Management, Hamburg, Germany

[8] Techniker Krankenkasse, Hamburg, Germany

[9] Deutsch Angestellten Krankenkasse, Supply Management, Bremen, Germany

[10] Barmer GEK, Berlin, Germany

[11] IKK Class, Dresden, Germany

来源：

SLEEP MEDICINE | 2019年 / 54卷

关键词：

Diabetes; Sleep duration; Napping; Kidney disease; eGFR; UACR; REPORTED SLEEP DURATION; GLOMERULAR-FILTRATION-RATE; RISK-FACTOR; POPULATION; PREVALENCE; ADULTS; APNEALINK(TM); HYPERTENSION; PROTEINURIA; DISORDERS;

D O I：

10.1016/j.sleep.2018.10.034

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Background: Diabetes-associated Kidney Disease (DKD) is a common comorbidity in patients with type 2 diabetes. The present study investigates whether daytime sleeping duration in patients, ill with type 2 diabetes, is associated with DKD. Methods: A total of 733 outpatients of the cross-sectional baseline survey of the DIACORE study were analyzed with respect to their self-reported daytime sleeping duration, assessed by a standardized questionnaire. DKD was defined as eGFR <60 ml/min/1.73 m(2) and/or urinary albumin-to-creatinine-ratio (UACR) > 30 mg/g. Results: Mean daytime sleeping duration was 17 +/- 27 min. With increasing daytime sleeping duration a statistically significant decrease in eGFR (p = 0.002) and increase in UACR (p < 0.001) were found, respectively. Prevalence of DKD was significantly higher in patients with longer daytime sleeping duration (31% in patients not napping, 40% in patients napping less than 30 min, 47% in patients napping 30-60 min, 56% in patients napping 60 min or more; p = 0.001). After accounting for known modulators (Age, sex, BMI, waist-hip-ratio, systolic and diastolic blood pressure, physical activity, diabetes duration, HbA1c, homeostasis model assessment (HOMA-Index), nighttime sleeping duration, apnea-hypopnea-index (AHI), Epworth Sleepiness Scale (ESS)), longer daytime sleeping duration was significantly associated with impaired eGFR [B (95% CI) = -0.05 (-0.09; 0.00), p = 0.044] and increased UACR [B (95% CI) = 0.01 (0.01; 0.02), p < 0.001], respectively. Conclusion: Increased daytime sleeping duration is significantly associated with reduced eGFR and higher UACR, independent of known modulators of DKD. The direction of this relationship remains unclear. (c) 2018 Elsevier B.V. All rights reserved.

引用

页码：205 / 212

页数：8