EMT in cancer

被引：1623

作者：

Brabletz, Thomas ^{[1
]}

Kalluri, Raghu ^{[2
]}

Angela Nieto, M. ^{[3
]}

Weinberg, Robert A. ^{[4
,5
]}

机构：

[1] FAU Univ Erlangen Nurnberg, Nikolaus Fiebiger Ctr Mol Med, Dept Expt Med 1, Gluckstr 6, D-91054 Erlangen, Germany

[2] Univ Texas MD Anderson Canc Ctr, Metastasis Res Ctr, Dept Canc Biol, Houston, TX 77054 USA

[3] CSIC UMH, Inst Neurociencias, Avda Ramon y Cajal S-N, Alacant 03550, Spain

[4] Ludwig Massachusetts Inst Technol MIT, Ctr Mol Oncol, Whitehead Inst Biomed Res, Cambridge, MA 02142 USA

[5] MIT, Dept Biol, Cambridge, MA 02142 USA

来源：

NATURE REVIEWS CANCER | 2018年 / 18卷 / 02期

基金：

欧洲研究理事会;

关键词：

EPITHELIAL-MESENCHYMAL TRANSITION; TUMOR-INITIATING CELLS; BREAST-CANCER; PANCREATIC-CANCER; CELLULAR PLASTICITY; DRUG-RESISTANCE; LUNG METASTASIS; STEM-CELLS; E-CADHERIN; ZEB1;

D O I：

10.1038/nrc.2017.118

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Similar to embryonic development, changes in cell phenotypes defined as an epithelial to mesenchymal transition (EMT) have been shown to play a role in the tumorigenic process. Although the first description of EMT in cancer was in cell cultures, evidence for its role in vivo is now widely reported but also actively debated. Moreover, current research has exemplified just how complex this phenomenon is in cancer, leaving many exciting, open questions for researchers to answer in the future. With these points in mind, we asked four scientists for their opinions on the role of EMT in cancer and the challenges faced by scientists working in this fast-moving field.

引用

页码：128 / +

页数：7

共 61 条

[1] Circulating Tumor Cell Clusters Are Oligoclonal Precursors of Breast Cancer Metastasis [J].

Aceto, Nicola ;

Bardia, Aditya ;

Miyamoto, David T. ;

Donaldson, Maria C. ;

Wittner, Ben S. ;

Spencer, Joel A. ;

Yu, Min ;

Pely, Adam ;

Engstrom, Amanda ;

Zhu, Huili ;

Brannigan, Brian W. ;

Kapur, Ravi ;

Stott, Shannon L. ;

Shioda, Toshi ;

Ramaswamy, Sridhar ;

Ting, David T. ;

Lin, Charles P. ;

Toner, Mehmet ;

Haber, Daniel A. ;

Maheswaran, Shyamala .

CELL, 2014, 158 (05) :1110-1122

[2] Upholding a role for EMT in pancreatic cancer metastasis [J].

Aiello, Nicole M. ;

Brabletz, Thomas ;

Kang, Yibin ;

Angela Nieto, M. ;

Weinberg, Robert A. ;

Stanger, Ben Z. .

NATURE, 2017, 547 (7661) :E7-E8

[3] Context-specific roles of EMT programmes in cancer cell dissemination [J].

Angela Nieto, M. .

NATURE CELL BIOLOGY, 2017, 19 (05) :416-418

[4] EMT: 2016 [J].

Angela Nieto, M. ;

Huang, Ruby Yun-Ju ;

Jackson, Rebecca A. ;

Thiery, Jean Paul .

CELL, 2016, 166 (01) :21-45

[5] Epithelial to Mesenchymal Transition Contributes to Drug Resistance in Pancreatic Cancer [J].

Arumugam, Thiruvengadam ;

Ramachandran, Vijaya ;

Fournier, Keith F. ;

Wang, Huamin ;

Marquis, Lauren ;

Abbruzzese, James L. ;

Gallick, Gary E. ;

Logsdon, Craig D. ;

McConkey, David J. ;

Choi, Woonyoung .

CANCER RESEARCH, 2009, 69 (14) :5820-5828

[6] The Snail genes as inducers of cell movement and survival: implications in development and cancer [J].

Barrallo-Gimeno, A ;

Nieto, MA .

DEVELOPMENT, 2005, 132 (14) :3151-3161

[7] Plasticity between Epithelial and Mesenchymal States Unlinks EMT from Metastasis-Enhancing Stem Cell Capacity [J].

Beerling, Evelyne ;

Seinstra, Danielle ;

de Wit, Elzo ;

Kester, Lennart ;

van der Velden, Daphne ;

Maynard, Carrie ;

Schafer, Ronny ;

van Diest, Paul ;

Voest, Emile ;

van Oudenaarden, Alexander ;

Vrisekoop, Nienke ;

van Rheenen, Jacco .

CELL REPORTS, 2016, 14 (10) :2281-2288

[8] The ZEB/miR-200 feedback loop-a motor of cellular plasticity in development and cancer? [J].

Brabletz, Simone ;

Brabletz, Thomas .

EMBO REPORTS, 2010, 11 (09) :670-677

[9] Variable β-catenin expression in colorectal cancers indicates tumor progression driven by the tumor environment [J].

Brabletz, T ;

Jung, A ;

Reu, S ;

Porzner, M ;

Hlubek, F ;

Kunz-Schughart, LA ;

Knuechel, R ;

Kirchner, T .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2001, 98 (18) :10356-10361

[10] To differentiate or not - routes towards metastasis [J].

Brabletz, Thomas .

NATURE REVIEWS CANCER, 2012, 12 (06) :425-436

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