A cascade palladium-mediated cross-coupling/electrocyclization approach to the construction of fused bi- and tricyclic rings

被引：38

作者：

Kan, S. B. Jennifer ^{[1
,2
]}

Anderson, Edward A. ^{[1
]}

机构：

[1] Univ Oxford, Chem Res Lab, Oxford OX1 3TA, England

[2] Univ Cambridge, Dept Chem, Cambridge CB2 1EW, England

来源：

ORGANIC LETTERS | 2008年 / 10卷 / 11期

基金：

英国工程与自然科学研究理事会;

关键词：

D O I：

10.1021/ol8007952

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A versatile palladium-catalyzed cyclization/cross-coupling/electrocyclization strategy for the synthesis of fused bi- and tricyclic ring systems is described. Excellent yields of the polycyclic products are obtained with a range of tethering ring sizes and functionality, including an unprecedented 5,6,4,5-fused tetracycle. The reaction mechanism features two unusual palladium-mediated isomerizations prior to electrocyclization.

引用

页码：2323 / 2326

页数：4

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