Recent Advances in the Synthesis of Enantiomerically Enriched Diaryl, Aryl Heteroaryl, and Diheteroaryl Alcohols through Addition of Organometallic Reagents to Carbonyl Compounds

Enantiomerically enriched diaryl, aryl heteroaryl, and dihetero-aryl alcohols are an important family of compounds known for their biological properties. Moreover, these molecules are highly privileged scaffolds used as building blocks for the synthesis of pharmaceutically relevant products. This short review provides background on the enantioselective arylation and heteroarylation of carbonyl compounds, as well as, the most significant improvements in this field with special emphasis on the application of organometallic reagents. 1 Introduction 2 Background on the Enantioselective Synthesis of Diaryl, Aryl Heteroaryl, and Diheteroaryl Alcohols 3Organozinc Reagents 4 Organolithium Reagents 5 Grignard Reagents 6 Organoaluminum Reagents 7 Organotitanium Reagents 8 Organobismuth Reagents 9 Miscellaneous 10 Conclusion