Recent Advances in the Synthesis of Enantiomerically Enriched Diaryl, Aryl Heteroaryl, and Diheteroaryl Alcohols through Addition of Organometallic Reagents to Carbonyl Compounds

被引:14
|
作者
Teixeira, Wystan K. O. [1 ]
de Albuquerque, Danilo Yano [1 ]
Narayanaperumal, Senthil [2 ]
Schwab, Ricardo S. [1 ]
机构
[1] Univ Fed Sao Carlos UFSCar, Ctr Excellence Res Sustainable Chem CERSusChem, Dept Quim, Rodovia Washington Luis,Km 235,SP 310, BR-13565905 Sao Carlos, SP, Brazil
[2] Dayananda SagarAcad Technol & Management DSATM, Dept Chem, Kanakapura Rd, Bengaluru 560082, India
来源
SYNTHESIS-STUTTGART | 2020年 / 52卷 / 13期
基金
巴西圣保罗研究基金会;
关键词
chiral alcohols; organometallic reagents; asymmetric addition; enantioselective arylation; heteroarylation; CATALYTIC ENANTIOSELECTIVE ARYLATION; ASYMMETRIC PHENYL TRANSFER; ORGANOZINC REAGENTS; GRIGNARD-REAGENTS; TITANIUM COMPLEXES; CHIRAL LIGANDS; BORONIC ACIDS; ORGANOMAGNESIUM REAGENTS; PROMOTED 1,2-ADDITIONS; ABSOLUTE-CONFIGURATION;
D O I
10.1055/s-0039-1690847
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
Enantiomerically enriched diaryl, aryl heteroaryl, and dihetero-aryl alcohols are an important family of compounds known for their biological properties. Moreover, these molecules are highly privileged scaffolds used as building blocks for the synthesis of pharmaceutically relevant products. This short review provides background on the enantioselective arylation and heteroarylation of carbonyl compounds, as well as, the most significant improvements in this field with special emphasis on the application of organometallic reagents. 1 Introduction 2 Background on the Enantioselective Synthesis of Diaryl, Aryl Heteroaryl, and Diheteroaryl Alcohols 3Organozinc Reagents 4 Organolithium Reagents 5 Grignard Reagents 6 Organoaluminum Reagents 7 Organotitanium Reagents 8 Organobismuth Reagents 9 Miscellaneous 10 Conclusion
引用
收藏
页码:1855 / 1873
页数:19
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