The anti-cancer and anti-inflammatory actions of 1,25(OH)2D3

被引：82

作者：

Vanoirbeek, E. ^{[1
]}

Krishnan, A. ^{[2
]}

Eelen, G. ^{[1
]}

Verlinden, L. ^{[1
]}

Bouillon, R. ^{[1
]}

Feldman, D. ^{[2
]}

Verstuyf, A. ^{[1
]}

机构：

[1] Katholieke Univ Leuven, Lab Expt Med & Endocrinol LEGENDO, Louvain, Belgium

[2] Stanford Univ, Sch Med, Div Endocrinol, Dept Med, Stanford, CA 94305 USA

来源：

BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM | 2011年 / 25卷 / 04期

关键词：

vitamin D; cancer; proliferation; apoptosis; metastasis; angiogenesis; inflammation; VITAMIN-D-RECEPTOR; NF-KAPPA-B; PROSTATE-CANCER CELLS; PHASE-II TRIAL; BREAST-CANCER; GENE-EXPRESSION; D ANALOG; 1,25-DIHYDROXYVITAMIN D-3; COX-2; EXPRESSION; MURINE MODEL;

D O I：

10.1016/j.beem.2011.05.001

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Various epidemiological studies have shown an aetiological link between vitamin D deficiency and cancer incidence. The active metabolite of vitamin D. 1,25-dihydroxyvitamin D-3 [1,25(OH)(2)D-3], has potent anti-cancer activities both in vitro and in vivo. These anti-cancer effects are attained by regulating the transcription of numerous genes that are involved in different pathways to reduce tumorigenesis and are dependent on the cancer cell type. Besides reducing cell growth and inducing apoptosis, 1,25(OH)(2)D-3 also inhibits angiogenesis and metastasis. Moreover, its potency to inhibit inflammation also contributes to its anti-tumoral activity. Here, we report the different ways in which 1,25(OH)(2)D-3 interferes with the malignant processes that are activated in cancer cells. (C) 2011 Elsevier Ltd. All rights reserved.

引用

页码：593 / 604

页数：12

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