Crucial role of interleukin-4 in the survival of colon cancer stem cells

被引：87
作者：
Francipane, Maria Giovanna [1 ]
Alea, Mileidys Perez [1 ]
Lombardo, Ylenia [1 ]
Todaro, Matilde [1 ]
Medema, J. P. [2 ]
Stassi, Giorgio [1 ]
机构：
[1] Dept Surg & Oncol Sci, Cellular & Mol Pathophysiol Lab, I-90127 Palermo, Italy
[2] Univ Amsterdam, Acad Med Ctr, Lab Expt Oncol & Radiobiol LEXOR, NL-1105 AZ Amsterdam, Netherlands
来源：
CANCER RESEARCH | 2008年 / 68卷 / 11期
关键词：
D O I：
10.1158/0008-5472.CAN-07-6874
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Colon tumors may be maintained by a rare fraction of cancer stem-like cells (CSC) that express the cell surface marker CD133. Self-renewing CSCs exhibit relatively greater resistance to clinical cytotoxic therapies and recent work suggests that this resistance may be mediated in part by an autocrine response to the immune cytokine interleukin 4 (IL-4). Blocking IL-4 signaling can sensitize CSCs to apoptotic stimuli and increase the in vivo efficacy of cytotoxic therapy. These findings suggest that inhibitors of IL-4 signaling may offer a new therapeutic tool in colon carcinoma.
引用
收藏
页码：4022 / 4025
页数：4
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