Cerebrospinal fluid tau levels are a marker for molecular subtype in sporadic Creutzfeldt-Jakob disease

被引:31
作者
Karch, Andre [1 ,2 ,3 ]
Hermann, Peter [2 ]
Ponto, Claudia [2 ]
Schmitz, Matthias [2 ,4 ]
Arora, Amandeep [2 ]
Zafar, Saima [2 ]
Llorens, Franc [2 ,4 ]
Mueller-Heine, Annika [5 ]
Zerr, Inga [2 ,4 ]
机构
[1] Helmholtz Ctr Infect Res, Epidemiol & Stat Methods ESME, Dept Epidemiol, D-38124 Braunschweig, Germany
[2] Univ Med Sch Gottingen, Clin Dementia Ctr, Natl Reference Ctr TSE, Gottingen, Germany
[3] German Ctr Infect Res DZIF, Hannover, Germany
[4] German Ctr Neurodegenerat Dis DZNE, Gottingen, Germany
[5] Hannover Med Sch MHH, Inst Biostat, Hannover, Germany
关键词
Creutzfeldt-Jakob disease; Tau; Biomarker; Subtype; Neurodegeneration; ALZHEIMERS-DISEASE; DIAGNOSIS; CRITERIA;
D O I
10.1016/j.neurobiolaging.2015.01.021
中图分类号
R592 [老年病学]; C [社会科学总论];
学科分类号
03 ; 0303 ; 100203 ;
摘要
The molecular subtype of sporadic Creutzfeldt-Jakob disease (sCJD) is an important prognostic marker for patient survival. However, subtype determination is not possible during lifetime. Because the rate of disease progression is associated with the molecular subtype, this study aimed at investigating if total tau, a marker of neuronal death, allows premortem diagnosis of molecular subtype when codon 129 genotype is known. Two hundred ninety-six sCJD patients were tested for their cerebrospinal fluid total tau level at the time of diagnosis and were investigated for their sCJD subtype postmortem. There was a significant association between tau levels and the prion protein type in patients with codon 129 MM (p < 0.001), MV (p = 0.004), and VV (p = 0.001) genotype. Receiver operating characteristic analyses showed values of area under the curve of 0.76-0.80 for the different genotypes indicating a good diagnostic validity of the test. Total tau can be used as a diagnostic test for the assessment of prion protein type when codon 129 genotype is known. It provides valuable information for physicians and next of kin about the further course of disease. (C) 2015 Elsevier Inc. All rights reserved.
引用
收藏
页码:1964 / 1968
页数:5
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