CXCL10/IP-10 in infectious diseases pathogenesis and potential therapeutic implications

被引：593
作者：
Liu, Mingli [1 ]
Guo, Shanchun [1 ]
Hibbert, Jacqueline M. [1 ]
Jain, Vidhan [2 ]
Singh, Neeru [2 ]
Wilson, Nana O. [1 ]
Stiles, Jonathan K. [1 ]
机构：
[1] Morehouse Sch Med, Dept Microbiol Biochem & Immunol, Atlanta, GA 30310 USA
[2] Natl Inst Malaria Res ICMR, Jabalpur, India
来源：
CYTOKINE & GROWTH FACTOR REVIEWS | 2011年 / 22卷 / 03期
基金：
美国国家卫生研究院;
关键词：
Chemokine; CXCL10; CXCR3; Infectious diseases; GAMMA-INDUCIBLE PROTEIN-10; CHEMOKINE RECEPTOR CXCR3; DECREASES SECONDARY DEGENERATION; MESSENGER-RNA EXPRESSION; MURINE CEREBRAL MALARIA; AIRWAY EPITHELIAL-CELLS; CENTRAL-NERVOUS-SYSTEM; IFN-GAMMA; TNF-ALPHA; PROTECTIVE IMMUNITY;
D O I：
10.1016/j.cytogfr.2011.06.001
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
C-X-C motif chemokine 10 (CXCL10) also known as interferon gamma-induced protein 10 kDa (IP-10) or small-inducible cytokine 810 is a cytokine belonging to the CXC chemokine family. CXCL I 0 binds CXCR3 receptor to induce chemotaxis, apoptosis, cell growth and angiostasis. Alterations in CXCL10 expression levels have been associated with inflammatory diseases including infectious diseases, immune dysfunction and tumor development. CXCL10 is also recognized as a biomarker that predicts severity of various diseases. A review of the emerging role of CXCL10 in pathogenesis of infectious diseases revealed diverse roles of CXCL10 in disease initiation and progression. The potential utilization of CXCL10 as a therapeutic target for infectious diseases is discussed. (C) 2011 Published by Elsevier Ltd.
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收藏
页码：121 / 130
页数：10
相关论文
共 134 条
  • [1] CXCR3 surface expression in human airway epithelial cells: cell cycle dependence and effect on cell proliferation
    Aksoy, MO
    Yang, Y
    Ji, R
    Reddy, PJ
    Shahabuddin, S
    Litvin, J
    Rogers, TJ
    Kelsen, SG
    [J]. AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY, 2006, 290 (05) : L909 - L918
  • [2] Identification of Stage Biomarkers for Human African Trypanosomiasis
    Amin, Daniel Ndem
    Ngoyi, Dieudonne Mumba
    Nhkwachi, Gondwe-Mphepo
    Palomba, Maria
    Rottenberg, Martin
    Buescher, Philippe
    Kristensson, Krister
    Masocha, Willias
    [J]. AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE, 2010, 82 (06) : 983 - 990
  • [3] HUMAN INTERFERON-INDUCIBLE PROTEIN-10 IS A POTENT INHIBITOR OF ANGIOGENESIS IN-VIVO
    ANGIOLILLO, AL
    SGADARI, C
    TAUB, DD
    LIAO, F
    FARBER, JM
    MAHESHWARI, S
    KLEINMAN, HK
    REAMAN, GH
    TOSATO, G
    [J]. JOURNAL OF EXPERIMENTAL MEDICINE, 1995, 182 (01) : 155 - 162
  • [4] Cerebrospinal fluid and serum biomarkers of cerebral malaria mortality in Ghanaian children
    Armah, Henry B.
    Wilson, Nana O.
    Sarfo, Bismark Y.
    Powell, Michael D.
    Bond, Vincent C.
    Anderson, Winston
    Adjei, Andrew A.
    Gyasi, Richard K.
    Tettey, Yao
    Wiredu, Edwin K.
    Tongren, Jon Eric
    Udhayakumar, Venkatachalam
    Stiles, Jonathan K.
    [J]. MALARIA JOURNAL, 2007, 6 (1)
  • [5] Estrogen disrupts chemokine-mediated chemokine release from mammary cells: implications for the interplay between estrogen and IP-10 in the regulation of mammary tumor formation
    Aronica, SM
    Fanti, P
    Kaminskaya, K
    Gibbs, K
    Raiber, L
    Nazareth, M
    Bucelli, R
    Mineo, M
    Grzybek, K
    Kumin, M
    Poppenberg, K
    Schwach, C
    Janis, K
    [J]. BREAST CANCER RESEARCH AND TREATMENT, 2004, 84 (03) : 235 - 245
  • [6] Antitumor/Antiestrogenic Effect of the Chemokine Interferon Inducible Protein 10 (IP-10) Involves Suppression of VEGF Expression in Mammary Tissue
    Aronica, Susan M.
    Raiber, Lisa
    Hanzly, Michael
    Kisela, Caroline
    [J]. JOURNAL OF INTERFERON AND CYTOKINE RESEARCH, 2009, 29 (02) : 83 - 91
  • [7] IFN-γ-inducible protein 10 and pentraxin 3 plasma levels are tools for monitoring inflammation and disease activity in Mycobacterium tuberculosis infection
    Azzurri, A
    Sow, OY
    Amedei, A
    Bah, B
    Diallo, S
    Peri, G
    Benagiano, M
    D'Elios, MM
    Mantovani, A
    Del Prete, G
    [J]. MICROBES AND INFECTION, 2005, 7 (01) : 1 - 8
  • [8] Regulation of endothelial cell adhesion molecule expression in an experimental model of cerebral malaria
    Bauer, PR
    Van der Heyde, HC
    Sun, G
    Specian, RD
    Granger, DN
    [J]. MICROCIRCULATION, 2002, 9 (06) : 463 - 470
  • [9] On the pathogenic role of brain-sequestered αβ CD8+ T cells in experimental cerebral malarial
    Belnoue, E
    Kayibanda, M
    Vigario, AM
    Deschemin, JC
    van Rooijen, N
    Viguier, M
    Snounou, G
    Rénia, L
    [J]. JOURNAL OF IMMUNOLOGY, 2002, 169 (11) : 6369 - 6375
  • [10] Belperio JA, 2000, J LEUKOCYTE BIOL, V68, P1
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