Controlling hair follicle signaling pathways through polyubiquitination

被引：10

作者：

Huntzicker, Erik G. ^{[1
]}

Oro, Anthony E. ^{[1
]}

机构：

[1] Stanford Univ, Sch Med, Program Epithelial Biol, Stanford, CA 94305 USA

来源：

JOURNAL OF INVESTIGATIVE DERMATOLOGY | 2008年 / 128卷 / 05期

关键词：

D O I：

10.1038/sj.jid.5700957

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Hair follicle development and maintenance require precise reciprocal signaling interactions between the epithelium and underlying dermis. Three major developmental signaling pathways, Wnt, Sonic hedgehog, and NF-kappa B/Edar, are indispensable for this process and, when aberrantly activated, can lead to skin and appendage neoplasms. Recent data point to protein polyubiquitination as playing a central role in regulating the timing, duration, and location of signaling. Here we review how polyubiquitination regulates the stability and interaction of key signaling components that control hair follicle development and regeneration.

引用

页码：1081 / 1087

页数：7

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