Sinomenium acutum: A Comprehensive Review of its Botany, Phytochemistry, Pharmacology and Clinical Application

被引：16

作者：

Ding, Chao ^{[1
]}

Li, Yuze ^{[1
]}

Sun, Yu ^{[1
]}

Wu, Ying ^{[1
]}

Wang, Fengrui ^{[1
]}

Liu, Chenwang ^{[1
]}

Zhang, Huawei ^{[1
]}

Jiang, Yi ^{[1
]}

Zhang, Dongdong ^{[1
]}

Song, Xiaomei ^{[1
]}

机构：

[1] Shaanxi Univ Chinese Med, Sch Pharm, 1 Middle Sect Century Ave, Xian Yang 712046, Shaanxi, Peoples R China

来源：

AMERICAN JOURNAL OF CHINESE MEDICINE | 2022年 / 50卷 / 05期

基金：

中国国家自然科学基金;

关键词：

Sinomenium acutum; Alkaloids; Pharmacological Activities; Clinical Application; Review; MORPHINANE ALKALOIDS; CAULIS; APOPTOSIS; PROLIFERATION; INFLAMMATION; INHIBITION; METABOLITE; AUTOPHAGY; PROGRESS; CELLS;

D O I：

10.1142/S0192415X22500501

中图分类号：

R [医药、卫生];

学科分类号：

10 ;

摘要：

Sinomenium acutum is the dry stem of Sinomenium acutum (Thunb.) Rehd et Wils. (S. acutum) and Sinomenium acutum (Thunb.) Rehd. et Wils. var. cinereum Rehd. et Wils and is mainly distributed in China and Japan. As a traditional Chinese medicine (TCM) for dispelling wind and dampness in China, it is widely distributed and has a long history of drug use. In recent years, with the increase of the incidence of rheumatoid disease, S. acutum has become the focus of research. This paper reviews the literature on the chemical constituents, pharmacological effects, clinical applications and pharmacokinetics and safety of S. acutum from the past 60 years. At present, more than 210 natural compounds have been isolated from S. acutum, including alkaloids, lignans, triterpenoid saponins, steroids, and other structures. Pharmacological activities of S. acutum were mainly reported on anti-inflammatory, analgesic, anti-allergic, immunosuppressive, anti-tumor, liver-protective, anti-oxidative, and other effects, and clinical applications were mainly recorded on rheumatoid arthritis, ankylosing spondylitis, and other diseases. The clinical use of SIN has fewer side effects and more safety; only a small number of gastrointestinal reactions occurred, and the symptoms disappeared after the drug stopped. The purpose of this paper is to lay a foundation and provide reference for the follow-up research and wide application of S. acutum.

引用

页码：1219 / 1253

页数：35