D-Peptides as Recognition Molecules and Therapeutic Agents

被引：57

作者：

Liu, Min ^{[1
]}

Li, Xue ^{[1
]}

Xie, Zuoxu ^{[1
]}

Xie, Cao ^{[1
]}

Zhan, Changyou ^{[1
,2
]}

Hu, Xuefeng ^{[1
]}

Shen, Qing ^{[1
]}

Wei, Xiaoli ^{[1
]}

Su, Bingxia ^{[1
]}

Wang, Jing ^{[1
]}

Lu, Weiyue ^{[1
]}

机构：

[1] Fudan Univ, Key Lab Smart Drug Delivery, Minist Educ, Dept Pharmaceut,Sch Pharm, 826 Zhangheng Rd, Shanghai 201203, Peoples R China

[2] Fudan Univ, Dept Pharmacol, Sch Basic Med Sci, 138 Yixueyuan Rd, Shanghai 200032, Peoples R China

来源：

CHEMICAL RECORD | 2016年 / 16卷 / 04期

基金：

美国国家科学基金会;

关键词：

mirror-image phage display; molecular recognition; peptides; retro-inverso; BLOOD-BRAIN-BARRIER; NATIVE CHEMICAL LIGATION; TARGETED DRUG-DELIVERY; RETRO-INVERSO-PEPTIDOMIMETICS; IMAGE PHAGE DISPLAY; MOUTH-DISEASE VIRUS; POLY(ETHYLENE GLYCOL)-CO-POLY(EPSILON-CAPROLACTONE) NANOPARTICLES; INTERSTITIAL FLUID PRESSURE; AMYLOID CASCADE HYPOTHESIS; ENDOTHELIAL GROWTH-FACTOR;

D O I：

10.1002/tcr.201600005

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Over recent years, D-peptides have attracted increasing attention. D-peptides increase enzymatic stability, prolong the plasma half-life, improve oral bioavailability, and enhance binding activity and specificity with receptor or target proteins, in comparison with the corresponding L-peptide. Therefore, D-peptides are considered to have potential as recognition molecules and therapeutic agents. This review focuses on the design and application of D-peptides with biological activity.

引用

页码：1772 / 1786

页数：15

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