A Critical Assessment of Exosomes in the Pathogenesis and Stratification of Parkinson's Disease

被引：66

作者：

Tofaris, George K. ^{[1
]}

机构：

[1] Univ Oxford, John Radcliffe Hosp, Nuffield Dept Clin Neurosci, Oxford OX3 9DU, England

来源：

JOURNAL OF PARKINSONS DISEASE | 2017年 / 7卷 / 04期

基金：

英国惠康基金; 英国工程与自然科学研究理事会;

关键词：

Aggregation; alpha-synuclein; biomarker; exosome; LRRK2; neurodegeneration; ALPHA-SYNUCLEIN; LRRK2; MUTATIONS; DEGRADATION; SECRETION; DEMENTIA; TOXICITY; DELIVERY; NEURONS; GENE;

D O I：

10.3233/JPD-171176

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Extracellular vesicles including exosomes are released by a variety of cell types including neurons and exhibit molecular profiles that reflect normal and disease states. As their content represents a snapshot of the intracellular milieu, they could be exploited as biomarkers of the otherwise inaccessible brain microenvironment. In addition they may contribute to the progression of neurodegenerative disorders by facilitating the spread of misfolded proteins at distant sites or activating immune cells. This review summarizes recent advances in the study of exosomes in Parkinson's disease pathophysiology and their potential as disease biomarkers.

引用

页码：569 / 576

页数：8

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