A convenient approach to the synthesis of 1-halomethyl-substituted 2,4,5,6-tetrahydro-1H-imidazo[1,2-a] [1] benzazepines

被引：1

作者：

Danyliuk, Ivanna Yu ^{[1
]}

Tolmachova, Valentyna S. ^{[2
]}

Rusanov, Eduard B. ^{[1
]}

Vovk, Mikhailo V. ^{[1
]}

机构：

[1] Natl Acad Sci Ukraine, Inst Organ Chem, 5 Alurmanska St, UA-02094 Kiev, Ukraine

[2] Natl Pedag Dragomanov Univ, 9 Pirogova St, UA-01601 Kiev, Ukraine

来源：

CHEMISTRY OF HETEROCYCLIC COMPOUNDS | 2021年 / 57卷 / 12期

关键词：

N-allyl-4,5-dihydro-3H-1-benzazepin-2-amines; benzazepines; 1-(halomethyl)-2,4,5,6-tetrahydro-1H-imidazo[1,2-a][1]benzazepines; 2-methoxy-4,5-dihydro-3H-1-benzazepinones; electrophilic cyclization; INTRAMOLECULAR AROMATIC SUBSTITUTIONS; DERIVATIVES; ARYLATION;

D O I：

10.1007/s10593-021-03042-x

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Intramolecular halocyclization of N-allyl-4,5-dihydro-3H-1-benzazepin-2-amines, obtained by consecutive methylation and allylamination of benzazepin-2-ones, by the action of N-iodo(bromo)succinimide in acetonitrile at room temperature lead to the formation 1-(iodo(bromo)methyl)-2,4,5,6-tetrahydro-1H-imidazo[1,2-a][1]benzazepines in high yields.

引用

页码：1187 / 1194

页数：8

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