Antiviral TRIMs: friend or foe in autoimmune and autoinflammatory disease?

被引:79
作者
Jefferies, Caroline [1 ]
Wynne, Claire [1 ]
Higgs, Rowan [2 ]
机构
[1] Royal Coll Surgeons Ireland, Dublin 2, Ireland
[2] Trinity Coll Dublin, Immunol Res Ctr, Sch Biochem & Immunol, Dublin 2, Ireland
基金
爱尔兰科学基金会;
关键词
NF-KAPPA-B; SYSTEMIC-LUPUS-ERYTHEMATOSUS; FAMILIAL MEDITERRANEAN FEVER; DEPENDENT CYTOKINE EXPRESSION; PRIMARY BILIARY-CIRRHOSIS; EMBRYONIC STEM-CELLS; ENDOGENOUS RETROVIRUSES; CITRULLINATED VIMENTIN; RHEUMATOID-ARTHRITIS; NLRP3; INFLAMMASOME;
D O I
10.1038/nri3043
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
The concept that viral sensing systems, via their ability to drive pro-inflammatory cytokine and interferon production, contribute to the development of autoimmune and autoinflammatory disease is supported by a wide range of clinical and experimental observations. Recently, the tripartite motif-containing proteins (TRIMs) have emerged as having key roles in antiviral immunity - either as viral restriction factors or as regulators of pathways downstream of viral RNA and DNA sensors, and the inflammasome. Given their involvement in these pathways, we propose that TRIM proteins contribute to the development and pathology of autoimmune and autoinflammatory conditions, thus making them potential novel targets for therapeutic manipulation.
引用
收藏
页码:617 / 625
页数:9
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