An Anticancer Role of Hydrogen Sulfide in Human Gastric Cancer Cells

被引：28
|
作者：
Zhang, Li [1 ]
Qi, Qi [1 ,2 ]
Yang, Jianqiang [1 ]
Sun, Dongsheng [1 ,3 ]
Li, Chunfeng [4 ]
Xue, Yingwei [4 ]
Jiang, Qiuying [5 ]
Tian, Ye [1 ]
Xu, Changqing [1 ]
Wang, Rui [6 ]
机构：
[1] Harbin Med Univ, Dept Pathophysiol, Harbin 150081, Peoples R China
[2] Univ Chinese Med, Affiliated Hosp Heilongjiang 1, Dept Pathol, Harbin 150040, Peoples R China
[3] Qiqihar Med Coll, Dept Pathophysiol, Qiqihar 161006, Peoples R China
[4] Harbin Med Univ, Affiliated Hosp 3, Dept Gastrointestinal Surg, Harbin 150081, Peoples R China
[5] Harbin Med Univ, Affiliated Hosp 2, Dept Oncol, Harbin 150081, Peoples R China
[6] Lakehead Univ, Dept Biol, Thunder Bay, ON P7B 5E1, Canada
来源：
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY | 2015年 / 2015卷
基金：
加拿大健康研究院;
关键词：
H2S; VASORELAXANT; INJURY;
D O I：
10.1155/2015/636410
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Hydrogen sulfide (H2S) can be synthesized in mammalian cells by cystathionine gamma-lyase (CSE) and/or cystathionine beta-synthase (CBS). Both CSE and CBS are expressed in rat gastric tissues but their role in human gastric neoplasia has been unclear. The aims of the present study were to detect CSE and CBS proteins in human gastric cancer and determine the effect of exogenous NaHS on the proliferation of gastric cancer cells. We found that both CSE and CBS proteins were expressed in human gastric cancer cells and upregulated in human gastric carcinoma mucosa compared with those in noncancerous gastric samples. NaHS induced apoptosis of gastric cancer cells by regulating apoptosis related proteins. Also, NaHS inhibited cancer cell migration and invasion. An antigastric cancer role of H2S is thus indicated.
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页数：8
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