Chemical Production from Methanol Using Natural and Synthetic Methylotrophs

被引：24
|
作者：
Chen, Arvin Y. [1 ]
Lan, Ethan I. [2 ]
机构：
[1] Natl Chiao Tung Univ, Inst Mol Med & Bioengn, Hsinchu 30010, Taiwan
[2] Natl Chiao Tung Univ, Dept Biol Sci & Technol, Hsinchu 30010, Taiwan
来源：
BIOTECHNOLOGY JOURNAL | 2020年 / 15卷 / 06期
关键词：
METHYLOBACTERIUM-EXTORQUENS AM1; L-LYSINE PRODUCTION; L-SERINE PRODUCTION; BACILLUS-METHANOLICUS; METHYLOPHILUS-METHYLOTROPHUS; OBLIGATE METHYLOTROPH; BIOLOGICAL CONVERSION; BIOSYNTHETIC-PATHWAY; ACID PRODUCTION; RESTING CELLS;
D O I：
10.1002/biot.201900356
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
Methanol as a chemical feedstock is becoming increasingly important as it is derived from natural gas and is a feasible end-product for captured carbon dioxide. Biological conversion of methanol through natural and synthetic methylotrophs increases the chemical repertoire and is an important direction for one carbon (C1) based chemical economy. Advances in the metabolic engineering and synthetic biology enable development of microbial cell factories for converting methanol into various platform chemicals. In this review, the current status of methanol utilizing microbial factory development is summarized. Also the development of synthetic methylotrophy and methanol-augmented bioproductions is discussed.
引用
收藏
页数：14
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