Alpha-1-Antitrypsin Deficiency and Bronchiectasis: A Concomitance or a Real Association?

被引：11

作者：

Sanduzzi, Alessandro ^{[1
]}

Ciasullo, Emanuele ^{[1
]}

Capitelli, Ludovica ^{[1
]}

Zamparelli, Stefano Sanduzzi ^{[2
]}

Bocchino, Marialuisa ^{[1
]}

机构：

[1] Univ Federico II, AORN Colli Monaldi Hosp, Dept Clin Med & Surg, Sect Resp Dis, Naples 80138, Italy

[2] Univ Luigi Vanvitelli, AORN Colli Monaldi Hosp, UOC Clin Pneumol SUN, Naples 80138, Italy

来源：

INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH | 2020年 / 17卷 / 07期

关键词：

alpha-1-antitrypsin deficiency; emphysema; bronchiectasis; respiratory infections; LUNG; ALPHA(1)-ANTITRYPSIN; IMMUNODEFICIENCY; MUTATION; THERAPY; DISEASE;

D O I：

10.3390/ijerph17072294

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

Alpha-1-antitrypsin deficiency (AATd) is a hereditary disease, mainly characterized by early onset and the lower lobes' predominant emphysema. Bronchiectasis is characterized by dilatation of the bronchial wall and a clinical syndrome whose features are a cough, sputum production and frequent respiratory exacerbations. In the literature, there are many papers concerning these two clinical entities, but there is still a lot of debate about a possible association between them, in particular about the frequency of their association and causal links. The aim of this short communication is to show the literature reports about the association between AATd and bronchiectasis to establish the state of the art and possible future developments in this research field.

引用

页数：7

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