Pathophysiology clinical manifestations, and prevention of ischemia-reperfusion injury

被引：510

作者：

Collard, CD ^{[1
]}

Gelman, S ^{[1
]}

机构：

[1] Harvard Univ, Brigham & Womens Hosp, Sch Med, Dept Anesthesiol Perioperat & Pain Med, Boston, MA 02115 USA

来源：

ANESTHESIOLOGY | 2001年 / 94卷 / 06期

关键词：

D O I：

10.1097/00000542-200106000-00030

中图分类号：

R614 [麻醉学];

学科分类号：

100217 ;

摘要：

Ischemia contributes to the pathogenesis of many perioperative clinical conditions. Although restoration of blood flow to an ischemic organ is essential to prevent irreversible cellular injury, reperfusion may augment tissue injury in excess of that produced by ischemia alone. Thus, cellular damage after reperfusion of previously viable ischemic tissue is defined as ischemia-reperfusion injury. The basic pathophysiology, clinical manifestations, and therapeutic strategies for the prevention of ischemia-reperfusion injury are reviewed.

引用

页码：1133 / 1138

页数：6

共 26 条

[11] Ischaemia-reperfusion injury to the intestine [J].

Kong, SE ;

Blennerhassett, LR ;

Heel, KA ;

McCauley, RD ;

Hall, JC .

AUSTRALIAN AND NEW ZEALAND JOURNAL OF SURGERY, 1998, 68 (08) :554-561

[12] THE BENEFICIAL EFFECT OF HUMAN RECOMBINANT SUPEROXIDE-DISMUTASE ON ACUTE AND CHRONIC REJECTION EVENTS IN RECIPIENTS OF CADAVERIC RENAL-TRANSPLANTS [J].

LAND, W ;

SCHNEEBERGER, H ;

SCHLEIBNER, S ;

ILLNER, WD ;

ABENDROTH, D ;

RUTILI, G ;

ARFORS, KE ;

MESSMER, K .

TRANSPLANTATION, 1994, 57 (02) :211-217

[13] VALUE OF SUPEROXIDE-DISMUTASE FOR PREVENTION OF MULTIPLE ORGAN FAILURE AFTER MULTIPLE TRAUMA [J].

MARZI, I ;

BUHREN, V ;

SCHUTTLER, A ;

TRENTZ, O ;

DEMLING, RH ;

BARONE, JE ;

BENDER, JS .

JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE, 1993, 35 (01) :110-120

[14] Reperfusion injury: A review of the pathophysiology, clinical manifestations and therapeutic options [J].

Maxwell, SRJ ;

Lip, GYH .

INTERNATIONAL JOURNAL OF CARDIOLOGY, 1997, 58 (02) :95-117

[15]

Neary P, 1999, ISCHAEMIA-REPERFUSION INJURY, P123

[16] Leukocyte endothelial cell adhesion:: avenues for therapeutic intervention [J].

Panés, J ;

Perry, M ;

Granger, DN .

BRITISH JOURNAL OF PHARMACOLOGY, 1999, 126 (03) :537-550

[17] CONTRIBUTIONS OF ISCHEMIA AND REPERFUSION TO MUCOSAL LESION FORMATION [J].

PARKS, DA ;

GRANGER, DN .

AMERICAN JOURNAL OF PHYSIOLOGY, 1986, 250 (06) :G749-G753

[18] REDUCTION OF THE EXTENT OF ISCHEMIC MYOCARDIAL INJURY BY NEUTROPHIL DEPLETION IN THE DOG [J].

ROMSON, JL ;

HOOK, BG ;

KUNKEL, SL ;

ABRAMS, GD ;

SCHORK, MA ;

LUCCHESI, BR .

CIRCULATION, 1983, 67 (05) :1016-1023

[19] Isoflurane, but not halothane, induces protection of human myocardium via adenosine A1 receptors and adenosine triphosphate-sensitive potassium channels [J].

Roscoe, AK ;

Christensen, JD ;

Lynch, C .

ANESTHESIOLOGY, 2000, 92 (06) :1692-1701

[20] Reactive oxygen species-induced molecular damage and its application in pathology [J].

Toyokuni, S .

PATHOLOGY INTERNATIONAL, 1999, 49 (02) :91-102

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