Pathophysiology clinical manifestations, and prevention of ischemia-reperfusion injury

被引：508

作者：

Collard, CD ^{[1
]}

Gelman, S ^{[1
]}

机构：

[1] Harvard Univ, Brigham & Womens Hosp, Sch Med, Dept Anesthesiol Perioperat & Pain Med, Boston, MA 02115 USA

来源：

ANESTHESIOLOGY | 2001年 / 94卷 / 06期

关键词：

D O I：

10.1097/00000542-200106000-00030

中图分类号：

R614 [麻醉学];

学科分类号：

100217 ;

摘要：

Ischemia contributes to the pathogenesis of many perioperative clinical conditions. Although restoration of blood flow to an ischemic organ is essential to prevent irreversible cellular injury, reperfusion may augment tissue injury in excess of that produced by ischemia alone. Thus, cellular damage after reperfusion of previously viable ischemic tissue is defined as ischemia-reperfusion injury. The basic pathophysiology, clinical manifestations, and therapeutic strategies for the prevention of ischemia-reperfusion injury are reviewed.

引用

页码：1133 / 1138

页数：6

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